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Özet

Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism and increases the risk of premature cardiovascular diseases. In patients with FH, platelet function may be activated; however, the extent of this activation and its etiology are unclear. We aimed to evaluate the mean platelet volume (MPV), a marker of platelet activation, in patients with FH. The study group consisted of 164 patients with FH and 160 control patients. Controls were matched for age, gender, hypertension, and smoking. The MPV was significantly higher in patients with FH than in controls (9.2 ± 0.4 vs 7.9 ± 0.6 fL, respectively; P < .001). Platelet count was significantly lower among patients with FH when compared to control patients (259 ± 51 vs 272 ± 56 × 10(3)/L, respectively; P = .03). In linear regression analysis, MPV was independently associated only with total cholesterol (β = .6, 95% confidence interval: 0.004-0.008, P < .001). We have shown that MPV was increased in patients with FH and that it was independently associated with total cholesterol level.

Anahtar Kelimeler

mean platelet volume | platelet activation | platelet count | familial hypercholesterolemia

Makale Türü	Özgün Makale
Makale Alt Türü	SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı	Angiology
Dergi ISSN	0003-3197
Dergi Tarandığı Indeksler	SCI
Dergi Grubu	Q4
Makale Dili	İngilizce
Basım Tarihi	02-2016
Cilt No	67
Sayı	2
Sayfalar	146 / 150
Doi Numarası	10.1177/0003319715579781
Makale Linki	http://journals.sagepub.com/doi/10.1177/0003319715579781

Atıf Sayıları
WoS	28

Increased Mean Platelet Volume in Familial Hypercholesterolemia

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