| Yazarlar (13) |
ERAY EROĞLU
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HİLMİ UMUT ÜNAL
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Prof. Dr. Aydın GÜÇLÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
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İSMAİL KOÇYİĞİT
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MURAT KARAMAN
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MUTLU SAĞLAM
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MUSTAFA GEZER
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AHMET TAŞ
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GÖKMEN ZARARSIZ
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TAYFUN EYİLETEN
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İBRAHİM AYDIN
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ÖZKAN GÜNGÖR
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MAHMUT İLKER YILMAZ
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| Özet |
| Profilin-1 is a ubiquitous, actin-binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin-1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1-5 CKD. Serum concentrations of profilin-1 levels were determined by enzyme-linked immunosorbent assay. Endothelium-dependent vasodilatation (flow-mediated dilatation [FMD]) and endothelium-independent vasodilatation (nitroglycerine-mediated dilatation [NMD]) of the brachial artery were assessed noninvasively, using high-resolution ultrasound. Both fatal and nonfatal CVE were significantly higher in patients with high profilin-1 levels. Kaplan-Meier survival curves showed that patients with profilin-1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin-1 levels above the median value (log-rank test, P < .001). This is the first study that demonstrates the serum profilin-1 is independently associated with endothelial dysfunction, cardiovascular events and survival in patients with CKD. |
| Anahtar Kelimeler |
| cardiovascular events | chronic kidney disease | endothelial dysfunction | profilin-1 | survival |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | European Journal of Clinical Investigation |
| Dergi ISSN | 0014-2972 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2017 |
| Cilt No | 47 |
| Sayı | 12 |
| Sayfalar | 12839 / 0 |
| Doi Numarası | 10.1111/eci.12839 |
| Makale Linki | http://doi.wiley.com/10.1111/eci.12839 |
| Atıf Sayıları | |
| WoS | 3 |
