| Yazarlar (10) |
Özkan Güngör
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Hilmi Umut Ünal
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Aydın Güçlü
Kırşehir Ahi Evran Üniversitesi, Türkiye |
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Mustafa Gezer
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Tayfun Eyileten
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Fatma Betül Güzel
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Orçun Altunören
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Yusuf Oğuz
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İsmail Koçyiğit
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Mahmut İlker Yılmaz
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| Özet |
| Increased inflammation, associated with the increase in chronic kidney disease (CKD) stage, has a very important influence in vascular injury and cardiovascular diseases. In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD and to determine their effect on vascular damage and cardiovascular events (CVE). This was an observational cohort study in which serum IL-33 and ST2 were obtained from 238 CKD (stages 1-5) patients. We examined the changes in IL-33/ST2 levels in CKD patients, as well as the association with a surrogate of endothelial dysfunction. Fatal and non-fatal CVE were recorded for a mean of 24 months. We also performed a COX regression analysis to determine the association of IL-33/ST2 levels with CVE and survival. IL-33 and ST2 levels were significantly increased and estimated glomerular filtration rates (eGFR) were decreased. Flow-mediated dilatation (FMD) was significantly decreased from stage 1 to stage 5 CKD. IL-33 and ST2 levels were associated with FMD, and ST2 was a predictor. Multivariate Cox analysis showed that the presence of diabetes mellitus, smoking, and proteinuria and haemoglobin, Hs-CRP, IL-33, and ST2 were associated with the risk of CVE. Kaplan-Meier survival curves showed that patients with IL-33 and ST2 levels below the median value (IL-33 = 132.6 ng/L, ST2 = 382.9 pg/mL) had a higher cumulative survival compared with patients who had IL-33 and ST2 levels above the median value (log-rank test, p = 0.000). This is the first study that demonstrates that serum IL-33 and ST2 are associated with vascular injury, cardiovascular events, and survival in CKD patients. |
| Anahtar Kelimeler |
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | PLOS ONE |
| Dergi ISSN | 1932-6203 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2017 |
| Cilt No | 12 |
| Sayı | 6 |
| Sayfalar | 178939 / 0 |
| DOI Numarası | 10.1371/journal.pone.0178939 |
| Makale Linki | http://dx.plos.org/10.1371/journal.pone.0178939 |
| Atıf Sayıları | |
| WoS | 46 |
