Simultaneous Headspace-GC-FID Analysis for Methanol and Ethanol in Blood, Saliva and Urine: Validation of Method and Comparison of Specimens
Yazarlar (8)
Gorkem Mergen Ministry of Justice - Turkey, Türkiye
Zeliha Kayaalti Ministry of Justice - Turkey, Türkiye
Emrah Dural Ministry of Justice - Turkey, Türkiye
Vugar Aliyev Ministry of Justice - Turkey, Türkiye
Seda Kaya Ministry of Justice - Turkey, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Ayse Karakus Ministry of Justice - Turkey, Türkiye
Tulin Soylemezoglu
Ministry of Justice - Turkey, Türkiye
Ministry of Justice - Turkey, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | LC GC EUROPE (Q4) | ||
| Dergi ISSN | 1471-6577 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2011 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 24 / 6 / 292–0 | DOI | – |
| Makale Linki | https://go.gale.com/ps/i.do?id=GALE%7CA236332220&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=15275949&p=AONE&sw=w | ||
| Özet |
| This study presents a headspace gas chromatography method with flame ionization detection (GC-FID) for the determination of ethanol and methanol content in biological fluids such as blood, urine, and saliva, emphasizing matrix effects onto headspace analytical results. In this context, a simultaneous procedure was established and validated, and it was revealed that headspace GC for methanol and ethanol determination in all routinely available biological fluids is applicable as a reference method and also in routine diagnostics and monitoring. GC was performed with a run time'of 6 min. The method showed linearity in the range of 50-400 mg/dL both for methanol and ethanol ([r. sup. 2]= 0.998 and [r. sup. 2]= 0.999, respectively) in all specimens with a detection and quantification limits less than 1.5 mg/dL and 2 mg/dL, respectively, as well as with good repeatability. Relative standard deviation and percent bias … |
| Anahtar Kelimeler |
