| Yazarlar (3) |
Prof. Dr. Aydın GÜÇLÜ
Ahi Evran Üniversitesi, Türkiye |
Fatih Mehmet Erdur
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Kültigin Türkmen
Necmettin Erbakan Üniversitesi, Türkiye |
| Özet |
| Despite diagnostic and therapeutic approaches, diabetic kidney disease (DKD) is the most common cause of end-stage renal disease worldwide. Sirtuins, a group of nicotinamid adenine dinucleotide (NAD) dependent enzymes, can deacetylase target enzymes that regulate a wide variety of cellular processes regarding protein, carbohydrate and lipid metabolism, mitochondrial homeostasis and programmed cell death mechanisms including autophagy and apoptosis. Among sirtuins, sirtuin 1 (SIRT1) has been the most studied one in the pathogenesis and progression of DKD. In recent years, the relation between SIRT1 and hypertension was also evaluated.In the present review, we aimed to represent the mechanisms of SIRT1 in glucose and lipid metabolism and in the pathogenesis of diabetes mellitus. We also sought to highlight the emerging role of SIRT1 in the pathogenesis and treatment of DKD and hypertension. |
| Anahtar Kelimeler |
| sirtuin1 | apoptosis | autophagy | diabetic kidney disease | hypertension |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Experimental and Clinical Endocrinology & Diabetes |
| Dergi ISSN | 0947-7349 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2016 |
| Cilt No | 124 |
| Sayı | 3 |
| Sayfalar | 131 / 139 |
| Doi Numarası | 10.1055/s-0035-1565067 |
| Makale Linki | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1565067 |
| Atıf Sayıları | |
| WoS | 31 |
