| Yazarlar (7) |
LEVENT DEMİRTAŞ
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Prof. Dr. Aydın GÜÇLÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
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FATİH MEHMET ERDUR
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EMİN MURAT AKBAŞ
|
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ADALET ÖZÇİÇEK
|
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DİDEM ONK
|
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KÜLTİGİN TÜRKMEN
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| Özet |
| The prevalence of diabetes mellitus (DM) is increasing secondary to increased consumption of food and decreased physical activity worldwide. Hyperglycaemia, insulin resistance and hypertrophy of pancreatic beta cells occur in the early phase of diabetes. However, with the progression of diabetes, dysfunction and loss of beta cells occur in both types 1 and 2 DM. Programmed cell death also named apoptosis is found to be associated with diabetes, and apoptosis of beta cells might be the main mechanism of relative insulin deficiency in DM. Autophagic cell death and apoptosis are not entirely distinct programmed cell death mechanisms and share many of the regulator proteins. These processes can occur in both physiologic and pathologic conditions including DM. Besides these two important pathways, endoplasmic reticulum (ER) also acts as a cell sensor to monitor and maintain cellular homeostasis. ER stress has been found to be associated with autophagy and apoptosis. This review was aimed to describe the interactions between apoptosis, autophagy and ER stress pathways in DM. |
| Anahtar Kelimeler |
| Apoptosis | autophagy | cell survival and death | diabetes mellitus | endoplasmic reticulum stress |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Indian Journal of Medical Research |
| Dergi ISSN | 0971-5916 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2016 |
| Cilt No | 144 |
| Sayı | 4 |
| Sayfalar | 515 / 524 |
| Doi Numarası | 10.4103/0971-5916.200887 |
| Atıf Sayıları | |
| WoS | 77 |
