Synthesis, Characterization, and Biological Activity of Di‐2‐pyridyl Ketone Aryl Hydrazone and Its Copper(II) Complex and the Interaction of Di‐2‐pyridyl Ketone Aryl Hydrazone with DNA Bases
Yazarlar (3)
Doç. Dr. Murat ÇINARLI Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Esin KIRAY Kırşehir Ahi Evran Üniversitesi, Türkiye
Çiğdem Yüksektepe Ataol Çankiri Karatekin Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2023 |
| Cilt / Sayı / Sayfa | 8 / 45 / – | DOI | 10.1002/slct.202303381 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202303381 | ||
| Özet |
| The development of antibiotic resistance has also increased the interest in hydrazones. In this paper, we describe the new aroyl hydrazone and its Cu(II) complex, which we synthesized. Aroyl hydrazone (HL) was prepared by the condensation reaction of 3‐hydroxy‐2‐naphthoic hydrazide with di‐2‐pyridyl ketone. Ligand (HL) and its transition metal complexes [CuL2] (1), have been characterized by elemental analysis, FT‐IR, UV‐Vis., 1H‐NMR, and LC–MS techniques. The molecular structure of HL, whose crystal structure could not be obtained, was elucidated by the DFT/B3LYP/6‐311+G(d, p) method. The optimized molecular structure, total energy, molecular orbital energy values, molecular electrostatic potential map, reactivity parameters, and interaction with DNA bases were investigated. Theoretical UV‐vis spectra of HL were obtained with TD‐DFT in different solvent environments. In addition, the ligand and … |
| Anahtar Kelimeler |
| 3-hydroxy-2-naphthoic hydrazide | Aroyl hydrazone | Biological activity | Cu(II) complex | DNA bases | Schiff bases |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |