| Yazarlar |
Mustafa Argun
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Kazım Üzüm
Türkiye |
|
Mehmet Fatih Sönmez
Türkiye |
|
Abdullah Özyurt
Toros Üniversitesi, Türkiye |
|
Derya Karabulut
Erciyes Üniversitesi, Türkiye |
|
Zeynep Soyer Sarıca
Türkiye |
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Sunay Ünalmış
Türkiye |
|
Özge Pamukçu
Türkiye |
|
Ali Baykan
Türkiye |
|
Figen Narin
Türkiye |
|
Ferhan Elmalı
Türkiye |
|
Nazmi Narin
Türkiye |
| Özet |
| Objective: The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in rats with doxorubicin cardiotoxicity. Methods: Wistar albino rats were used in the study. Forty male, 10-week-old Wistar albino rats were randomly divided four groups. The control group rats were intraperitoneally administered saline solution twice a week, four doses in total. The doxorubicin group rats received doxorubicin (4 mg/kg, twice a week, cumulative dose: 16 mg/kg) intraperitoneally. The metformin group rats received metformin (250 mg/kg/day, every day for 14 days) via gavage. The doxorubicin + metformin group rats received doxorubicin and metformin at the same dose. Left ventricular functions were evaluated by using M-mode echocardiography one day after the last dose of doxorubicin. Heart tissue samples were histopathologically examined. Cardiomyocyte apoptosis was detected using in situ terminal deoxynucleotide transferase assay (TUNEL). Serum brain natriuretic peptide and C-type natriuretic peptide levels were measured. Catalase, superoxide dismutase, glutathione peroxidase, and tumor necrosis factor alpha levels were analyzed in the heart tissue. The assumptions of equality of variances and normal distribution were checked for all variables (Shapiro-Wilk test and Q-Q graphics). To identify intergroup differences, one-way variant analysis or the Kruskal-Wallis test was used. A p<0.05 value was accepted as statistically significant. Results: Our results showed that doxorubicin treatment caused significant deterioration in left ventricular functions by echocardiography, histological heart tissue damage, and increase in cardiomyocyte apoptosis. Doxorubicin + metformin group showed protection in left ventricular function, elimination of histopathologic change, and reduced of cardiomyocyte apoptosis. Conclusion: The present study provided evidence that metformin has cardioprotective effects against doxorubicin cardiotoxicity. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ANATOLIAN JOURNAL OF CARDIOLOGY |
| Dergi ISSN | 2149-2263 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2016 |
| Cilt No | 16 |
| Sayı | 4 |
| Sayfalar | 242 / 243 |
| Doi Numarası | 10.14744/AnatolJCardiol.2016.18505 |
| Makale Linki | http://dx.doi.org/10.5152/akd.2015.6185 |
| Atıf Sayıları | |
| WoS | 57 |
