Protective effects of propolis on methotrexate-induced testis injury in rat
Yazarlar (6)
Mehmet Fatih Sönmez
Erciyes University, Türkiye
Erciyes University, Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Derya Karabulut Erciyes Üniversitesi, Türkiye
Sunay Ünalmış
Erciyes University, Türkiye
Erciyes University, Türkiye
Erkan Deligönül
Fatih University, Türkiye
Fatih University, Türkiye
Emin Kaymak Erciyes University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOMEDICINE & PHARMACOTHERAPY (Q1) | ||
| Dergi ISSN | 0753-3322 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2016 |
| Cilt / Sayı / Sayfa | 79 / 0 / 44–51 | DOI | 10.1016/j.biopha.2016.02.002 |
| Makale Linki | http://dx.doi.org/10.1016/j.biopha.2016.02.002 | ||
| Özet |
| Propolis is an adhesive substance which is collected and used by honeybees. Propolis is a potent antioxidant and a free radical scavenger. This study was designed to determine whether propolis could protect against dysfunction and oxidative stress induced by methotrexate-induced injury in rat testis.A total of 40 male Wistar albino rats were divided into four groups: group 1 was the untreated control. On the eighth day of the experiment, groups 2 and 3 received single intraperitoneal injections of methotrexate (MTX) at 20 mg/kg. Groups 3 and 4 received 100 mg/kg/day propolis (by oral gavage) for 15 days by the first day of the experimental protocol. Then the rats were decapitated under anesthesia, and their testes were removed. The histopathological and biochemical analysis along with apoptosis assessment of testis tissues were compared. Immunohistochemical analysis of Heat shock protein-70 (HSP-70) and … |
| Anahtar Kelimeler |
| Methotrexate | Propolis | HSP-70 | Apoptosis | Testis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 79 |
| Web of Science | 43 |