Ameliorative effect of propolis on the cadmium-induced reproductive toxicity in male albino rats
Yazarlar (3)
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
İsmet Öztürk
Erciyes University, Türkiye
Erciyes University, Türkiye
Mehmet Fatih Sönmez
Erciyes University, Türkiye
Erciyes University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | EXPERIMENTAL AND MOLECULAR PATHOLOGY (Q2) | ||
| Dergi ISSN | 0014-4800 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2016 |
| Cilt / Sayı / Sayfa | 101 / 2 / 207–213 | DOI | 10.1016/j.yexmp.2016.08.004 |
| Makale Linki | http://dx.doi.org/10.1016/j.yexmp.2016.08.004 | ||
| Özet |
| Propolis is a potent antioxidant and a free radical scavenger. The present study aimed to investigate protective effects of propolis extract on cadmium-induced testicular damage, apoptosis, HIF-1α expression and toxicity in rat's testis tissue.A total of 32 male rats were equally divided into four study groups namely, control, Cd (1 mg/kg/day), Cd + propolis (50 mg/kg/day) and propolis. The rats were decapitated under ketamine anesthesia and their testes tissues were removed. Serum testosterone, tissue malondialdehyde and HIF-1α levels, HIF-1α expression, apoptosis and histopathological damage scores were then compared.In the Cd group, the diameters of seminiferous tubules, tubular biopsy score of Johnsen and serum testosterone levels were decreased compared control group, but tissue HIF-1α and tissue MDA levels was higher than control group. The immunoreactivity of HIF-1α and the number of apoptotic … |
| Anahtar Kelimeler |
| Cadmium | Propolis | HIF-1 alpha | Apoptosis | Testis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 45 |
| Web of Science | 29 |