Nitric oxide synthase in diabetic rat testicular tissue and the effects of pentoxifylline therapy
Yazarlar (6)
Mehmet Fatih Sönmez
Türkiye
Türkiye
Eser Kılıç Türkiye
Derya Karabulut Erciyes Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Erkan Deligönül
Türkiye
Türkiye
Munis Dündar Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE | ||
| Dergi ISSN | 1939-6368 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 62 / 1 / 22–30 | DOI | 10.3109/19396368.2015.1085605 |
| Makale Linki | https://www.tandfonline.com/doi/epdf/10.3109/19396368.2015.1085605?needAccess=true | ||
| Özet |
| Diabetes is known to be associated with erectile dysfunction, retrograde ejaculation, level of testicular hormone, and a decrease in semen quality, respectively. In this project, we aimed to investigate at the molecular level, the effects of NOS on testes pathology in diabetes and examine the effects of pentoxifylline on healing. A total of 50 Wistar albino male rats were divided into five groups: Group I control; Group II only diabetes; Group III and IV diabetes + pentoxifylline; Group V only pentoxifylline. Group III rats received 50 mg/kg/day pentoxifylline during two months. In comparison, Group IV rats received saline in the first month followed by 50 mg/kg/day of pentoxifylline for the following month. NOS expression in testicular tissue was assessed using qRT-PCR, western blot, and immunohistochemistry. The mean seminiferous tubule diameter, Johnsen's testicular biopsy score, and serum testosterone levels … |
| Anahtar Kelimeler |
| Diabetes mellitus | eNOS | iNOS | nNOS | rat | testes |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 33 |
| Web of Science | 23 |