| Yazarlar (6) |
Mehmet Fatih Sönmez
Türkiye |
|
Eser Kılıç
Türkiye |
|
Derya Karabulut
Erciyes Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Erkan Deligönül
Türkiye |
|
Munis Dündar
Türkiye |
| Özet |
| Diabetes is known to be associated with erectile dysfunction, retrograde ejaculation, level of testicular hormone, and a decrease in semen quality, respectively. In this project, we aimed to investigate at the molecular level, the effects of NOS on testes pathology in diabetes and examine the effects of pentoxifylline on healing. A total of 50 Wistar albino male rats were divided into five groups: Group I control; Group II only diabetes; Group III and IV diabetes + pentoxifylline; Group V only pentoxifylline. Group III rats received 50 mg/kg/day pentoxifylline during two months. In comparison, Group IV rats received saline in the first month followed by 50 mg/kg/day of pentoxifylline for the following month. NOS expression in testicular tissue was assessed using qRT-PCR, western blot, and immunohistochemistry. The mean seminiferous tubule diameter, Johnsen's testicular biopsy score, and serum testosterone levels … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Systems Biology in Reproductive Medicine |
| Dergi ISSN | 1939-6368 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2016 |
| Cilt No | 62 |
| Sayı | 1 |
| Sayfalar | 22 / 30 |
| Makale Linki | https://www.tandfonline.com/doi/epdf/10.3109/19396368.2015.1085605?needAccess=true |
