Evaluation of the effect of intranasal infiltrated botulinum toxin-A on a model of allergic rhinitis in rabbits: An Experimental Study
Yazarlar (9)
Murat Salih Güneş
Türkiye
Türkiye
PROFESÖR İsmail Külahlı Akdeniz Üniversitesi, Türkiye
Kerem Kökoğlu Erciyes Üniversitesi, Türkiye
Alperen Vural İstanbul Üniversitesi-Cerrahpaşa, Türkiye
Deniz Avcı Türkiye
Şafak Güleç İstanbul Medipol Üniversitesi, Türkiye
Mehmet Fatih Sönmez
Türkiye
Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Barış Derya Erçal
Türkiye
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International journal of pediatric otorhinolaryngology (Q3) | ||
| Dergi ISSN | 0165-5876 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2016 |
| Cilt / Sayı / Sayfa | 83 / 0 / 51–56 | DOI | 10.1016/j.ijporl.2016.01.010 |
| Makale Linki | http://dx.doi.org/10.1016/j.ijporl.2016.01.010 | ||
| Özet |
| IntroductionAllergic Rhinitis (AR) effects 20–40% of the global population and its prevalance increases. Medical treatment and immunotherapy could be used in AR management. But they are not definitive solution. Medical treatment must be used a long time and has side effects. Immunotherapy cannot be applied to every patient and it also takes a long time. The aim of this study is to evaluate symptomatic and histopathological effects of intranasal infiltrated Botulinum Toxin-A (Btx-A) on an animal model of AR.Material-Method15 rabbits were divided into 3 groups as control, disease and treatment. AR was formed in disease and treatment groups by intraperitoneal and intranasal ovalbumine. Allergic symptoms were observed and serum IgE levels were estimated to prove forming of AR. Btx-A was infiltrated in inferior turbinates of rabbits in treatment group. Rabbits were sacrified on 32nd day. Paranasal structures … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 11 |