Effects of Lycopene in Hyperoxia-Induced Lung Injury in Newborn Rats
Yazarlar (10)
Osman Baştuğ
Erciyes University, Türkiye
Erciyes University, Türkiye
Mehmet Fatih Sönmez
Erciyes University, Türkiye
Erciyes University, Türkiye
Mehmet Adnan Öztürk
Erciyes University, Türkiye
Erciyes University, Türkiye
Levent Korkmaz Erciyes University, Türkiye
Hakan Kesici Tokat Gaziosmanpasa University, Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Hülya Halis
Türkiye
Türkiye
Sabriye Korkut
Erciyes University, Türkiye
Erciyes University, Türkiye
Tamer Güneş
Erciyes University, Türkiye
Erciyes University, Türkiye
Selim Kurtoğlu
Erciyes University, Türkiye
Erciyes University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (Q4) | ||
| Dergi ISSN | 0300-9831 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2018 |
| Cilt / Sayı / Sayfa | 88 / 5 / 270–280 | DOI | 10.1024/0300-9831/a000238 |
| Makale Linki | http://dx.doi.org/10.1024/0300-9831/a000238 | ||
| Özet |
| The aim of this study was to evaluate the therapeutic effect of lycopene on a hyperoxia-induced lung injury model in rat pups. Full-term rat pups were included in the study 12–24 h after delivery. The pups were separated into 4 groups: normoxia control (NC), hyperoxia control (HC), hyperoxia+ lycopene (HL), and normoxia lycopene (NL). The normoxia groups were housed in ambient air, and the hyperoxia groups in> 85% O 2. HL and NL groups received 50 mg lycopene in oil/kg body weight/day delivered intraperitoneally (ip), the other groups received oil alone. On day 11, the rat pups were sacrificed and their lungs removed. Statistically significant injury was observed in all histological parameters measured (MLI, proliferating cell nuclear antigen (PCNA), and apoptosis) in the HC group (HC vs NC, p= 0.001). This injury could not be reversed with lycopene treatment (HC vs HL, 0.05; NC vs HL, p= 0.001). With … |
| Anahtar Kelimeler |
| Hyperoxic lung injury | lycopene | newborn | rat pups | toxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 3 |
| Web of Science | 2 |