| Yazarlar |
Osman Baştuğ
Türkiye |
|
Mehmet Fatih Sönmez
Türkiye |
|
Mehmet Adnan Öztürk
Türkiye |
|
Levent Korkmaz
Türkiye |
|
Hakan Kesici
Türkiye |
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Hülya Halis
Türkiye |
|
Sabriye Korkut
Türkiye |
|
Tamer Güneş
Türkiye |
|
Selim Kurtoğlu
Türkiye |
| Özet |
| The aim of this study was to evaluate the therapeutic effect of lycopene on a hyperoxia-induced lung injury model in rat pups. Fullterm rat pups were included in the study 12-24 h after delivery. The pups were separated into 4 groups: normoxia control (NC), hyperoxia control (HC), hyperoxia + lycopene (HL), and normoxia lycopene (NL). The normoxia groups were housed in ambient air, and the hyperoxia groups in > 85% O-2. HL and NL groups received 50 mg lycopene in oil/kg body weight/day delivered intraperitoneally (i.p.), the other groups received oil alone. On day 11, the rat pups were sacrificed and their lungs removed. Statistically significant injury was observed in all histological parameters measured (MLI, proliferating cell nuclear antigen (PCNA), and apoptosis) in the HC group (HC vs NC, p = 0.001). This injury could not be reversed with lycopene treatment (HC vs HL, 0.05; NC vs HL, p = 0.001). With hyperoxia, statistically significant decreases were observed in biochemical parameters in terms of SOD, MDA, and IL-6 values (HC vs NC: SOD, p = 0.02; MDA, p = 0.043; IL-6, p = 0.001). The use of lycopene did not provide any improvement in these values (HC vs HL, p > 0.05). Hyperoxia or lycopene had no effect on IL-1 beta and GPx (p > 0.05). When comparing NC and NL groups, negative effects were observed in the group given lycopene in terms of MLI, PCNA, apoptosis, and IL-6 (all parameters, p = 0.001). We observed that 50 mg lycopene in oil/kg body weight/day given via i.p. had no curative effect on the hyperoxia-induced lung injury in newborn rats and may even induce adverse effects. |
| Anahtar Kelimeler |
| Hyperoxic lung injury | lycopene | newborn | rat pups | toxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH |
| Dergi ISSN | 0300-9831 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2018 |
| Cilt No | 88 |
| Sayı | 5 |
| Sayfalar | 270 / 280 |
| Doi Numarası | 10.1024/0300-9831/a000238 |
| Makale Linki | http://dx.doi.org/10.1024/0300-9831/a000238 |
| Atıf Sayıları | |
| WoS | 2 |
