Effects of Lycopene in Hyperoxia-Induced Lung Injury in Newborn Rats
Yazarlar (10)
Osman Baştuğ Erciyes University, Türkiye
Mehmet Fatih Sönmez Erciyes University, Türkiye
Mehmet Adnan Öztürk Erciyes University, Türkiye
Levent Korkmaz Erciyes University, Türkiye
Hakan Kesici Tokat Gaziosmanpasa University, Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Erciyes University, Türkiye
Hülya Halis Türkiye
Sabriye Korkut Erciyes University, Türkiye
Tamer Güneş Erciyes University, Türkiye
Selim Kurtoğlu Erciyes University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (Q4) | ||
| Dergi ISSN | 0300-9831 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2018 |
| Cilt / Sayı / Sayfa | 88 / 5 / 270–280 | DOI | 10.1024/0300-9831/a000238 |
| Makale Linki | http://dx.doi.org/10.1024/0300-9831/a000238 | ||
| Özet |
| The aim of this study was to evaluate the therapeutic effect of lycopene on a hyperoxia-induced lung injury model in rat pups. Fullterm rat pups were included in the study 12-24 h after delivery. The pups were separated into 4 groups: normoxia control (NC), hyperoxia control (HC), hyperoxia + lycopene (HL), and normoxia lycopene (NL). The normoxia groups were housed in ambient air, and the hyperoxia groups in > 85% O-2. HL and NL groups received 50 mg lycopene in oil/kg body weight/day delivered intraperitoneally (i.p.), the other groups received oil alone. On day 11, the rat pups were sacrificed and their lungs removed. Statistically significant injury was observed in all histological parameters measured (MLI, proliferating cell nuclear antigen (PCNA), and apoptosis) in the HC group (HC vs NC, p = 0.001). This injury could not be reversed with lycopene treatment (HC vs HL, 0.05; NC vs HL, p = 0.001). With hyperoxia, statistically significant decreases were observed in biochemical parameters in terms of SOD, MDA, and IL-6 values (HC vs NC: SOD, p = 0.02; MDA, p = 0.043; IL-6, p = 0.001). The use of lycopene did not provide any improvement in these values (HC vs HL, p > 0.05). Hyperoxia or lycopene had no effect on IL-1 beta and GPx (p > 0.05). When comparing NC and NL groups, negative effects were observed in the group given lycopene in terms of MLI, PCNA, apoptosis, and IL-6 (all parameters, p = 0.001). We observed that 50 mg lycopene in oil/kg body weight/day given via i.p. had no curative effect on the hyperoxia-induced lung injury in newborn rats and may even induce adverse effects. |
| Anahtar Kelimeler |
| Hyperoxic lung injury | lycopene | newborn | rat pups | toxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 3 |