Protective effect of melatonin on blood-brain barrier damage caused by Endotoxemia
Yazarlar (4)
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Mukaddes Eşrefoğlu Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Şule Terzioğlu Uşak
Erfe Grp Co, Türkiye
Erfe Grp Co, Türkiye
Arzu Hanım Yay Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NEUROLOGICAL RESEARCH (Q4) | ||
| Dergi ISSN | 0161-6412 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2024 |
| Cilt / Sayı / Sayfa | 46 / 2 / 195–206 | DOI | 10.1080/01616412.2023.2265244 |
| Makale Linki | http://dx.doi.org/10.1080/01616412.2023.2265244 | ||
| Özet |
| ObjectiveEndotoxins, products of Gram-negative bacteria, are the primary cause of blood-brain barrier (BBB) damage. In the present study, we aimed to investigate the possible neuroprotection mechanisms of melatonin on BBB damage induced by endotoxemia.MethodsAdult, female Sprague-Dawley rats (n = 42) were separated into four random groups as a control group and three treatment groups. Lipopolysaccharide (7,5 mg/kg/day) was administrated for a single dose to generate a 24-hour sepsis model on rats. Melatonin (10 mg/kg/day) was treated a week before sepsis. Afterward, the dissected brain tissues were examined by histopathological, biochemical, and molecular analyses.ResultsLPS caused weight loss in the groups. As a result, degenerated neurons with cytoplasmic vacuoles and irregular pyknotic nuclei, pale stained necrotic neurons, and vascular congestion were observed in LPS-exposed … |
| Anahtar Kelimeler |
| Endotoxemia | lipopolysaccharide | melatonin | brain | rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |
| Web of Science | 1 |