Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage
Yazarlar (7)
Mukaddes Eşrefoğlu Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Ersin Karataş Türkiye
Birsen Elibol Türkiye
Emine Rümeysa Hekimoğlu Türkiye
Fatma Bedia Karakaya Türkiye
Arzu Hanım Yay Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Immunopharmacology and Immunotoxicology (Q2) | ||
| Dergi ISSN | 0892-3973 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2024 |
| Cilt / Sayı / Sayfa | 46 / 1 / 1–17 | DOI | 10.1080/08923973.2023.2291751 |
| Makale Linki | https://doi.org/10.1080/08923973.2023.2291751 | ||
| Özet |
| AimOne of the serious complications of sepsis is liver damage and liver failure. This study aimed to evaluate the protective and therapeutic potential of melatonin in rats with lipopolysaccharide-induced sepsis.Main methodsFemale Spraque-Dawley rats received single a dose of 7.5 mg/kg lipopolysaccharide in saline to create a 24-h sepsis model. One of the other groups received melatonin at a dose of 10 mg/kg/day beginning 1 week before sepsis induction to the end of the experiment. The melatonin group received the same doses of melatonin for the same duration but not lipopolysaccharide. The vehicle group received the same doses of saline, the vehicle of melatonin, for the same duration. Twenty-four hours after the last injection, the rats were decapitated. By appropriate histochemical, immunohistochemical, biochemical, and molecular techniques, anti-necrotic, anti-apoptotic, anti-necroptotic, anti-inflammatory, and antioxidant effects of melatonin were assessed.Key findingsLipopolysaccharide has disrupted liver functions by inducing oxidative stress, inflammation, necrotic, apoptotic, and necroptotic cell death, thus disrupting liver functions. Melatonin was found to be beneficial in terms of inhibiting the intrinsic pathway of apoptosis and tissue oxidant levels, stimulating tissue antioxidant enzyme levels, and restoring hepatocyte functions.SignificanceMelatonin, at those doses and duration, was found to be hepatoprotective by mainly modulating oxidative status and apoptosis rate, however, failed to significantly reduce histopathological damage. We suggest that longer-term melatonin administration may produce anti-inflammatory and anti-necrotic effects as well. |
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| Google Scholar | 3 |