| Yazarlar (10) |
Prof. Dr. Aydın GÜÇLÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
MAHMUT İLKER YILMAZ
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TURGUT TURSEM TOKMAK
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HİLMİ UMUT ÜNAL
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MURAT KARAMAN
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MUSTAFA GEZER
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AHMET TAŞ
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İBRAHİM AYDIN
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RAZİYE AKCILAR
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YUSUF DURSUN
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| Özet |
| Increasing evidence suggests that inflammation and increased macrophage activity have a central role in pathogenesis of atherosclerosis. It is shown that chitotriosidase (CHIT-1) is a marker of macrophage activity in atherosclerotic plaque, and is found associated with severity of atherosclerotic lesion. There is no data about CHIT-1 activity of hemodialysis patients in the literature. Thus, we hypothesized that in hemodialysis patients, CHIT-1 levels might be a novel biomarker in early atherosclerosis. Forty-five hemodialysis patients were included in the study (age: 61.93 ± 13.34). Intima media thickness (IMT) was evaluated with high-resolution B-mode ultrasonography. Biomarker levels were measured in serum of patients. We found positive correlation among IMT, age (R: 0.426, P: 0.004) and, CHIT-1 value (R: 0.462, P: 0.001) in spearman correlation analysis. When age, CRP, creatinine, P, Alb, CHIT-1 were chosen as measures that can effect IMT in multiple regression model, IMT level was related with CHIT-1 (Beta: 0,396, P: 0.012) and age (Beta: 0,313 P: 0,048) independently. In conclusion, this is the first report showing that serum CHIT-1 level was related independently with carotid IMT in hemodialysis patients. This biomarker might have an unknown role in the development of atherosclerosis during uremia. |
| Anahtar Kelimeler |
| Chitotriosidase (CHIT-1) | atherosclerosis | intima media thickness | hemodialysis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Hemodialysis International |
| Dergi ISSN | 1492-7535 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 21 |
| Sayı | 1 |
| Sayfalar | 41 / 46 |
| Doi Numarası | 10.1111/hdi.12451 |
| Makale Linki | http://doi.wiley.com/10.1111/hdi.12451 |
| Atıf Sayıları | |
| WoS | 4 |
