| Yazarlar |
Sule Darbas
|
|
Dilara Inan
|
|
Yahya Kilinc
|
Dr. Öğr. Üyesi Habibe Sema ARSLAN
Kırşehir Ahi Evran Üniversitesi |
|
Fahri Ucar
|
|
Ozaydin Boylubay
|
|
Sadi Koksoy
|
|
Esvet Mutlu
|
|
Burcu Yucel
|
|
Nurten Sayin Ekinci
|
| Özet |
| OBJECTIVE: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye.METHODS: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by sequence-based high-resolution typing.RESULTS: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant. CONCLUSION: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection. |
| Anahtar Kelimeler |
| Antiretroviral therapy, HIV, HLA-B alleles distribution, hypersensitivity reaction |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | NORTHERN CLINICS OF ISTANBUL |
| Dergi ISSN | 2148-4902 |
| Makale Dili | İngilizce |
| Basım Tarihi | 1-2023 |
| Cilt No | 10 |
| Sayı | 1 |
| Sayfalar | 67 / 73 |
| Doi Numarası | 10.14744/nci.2021.00018 |
| Atıf Sayıları |
