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Synthesis, Characterization, and Biological Activity of Di-2- pyridyl Ketone Aryl Hydrazone and Its Copper(II) Complex and the Interaction of Di-2-pyridyl Ketone Aryl Hydrazone with DNA Base     
Yazarlar
Dr. Öğr. Üyesi Murat ÇINARLI
Türkiye
Dr. Öğr. Üyesi Esin KIRAY
Kırşehir Ahi Evran Üniversitesi, Türkiye
Çiğdem Yüksektepe Ataol
Türkiye
Özet
The development of antibiotic resistance has also increased the interest in hydrazones. In this paper, we describe the new aroyl hydrazone and its Cu(II) complex, which we synthesized. Aroyl hydrazone (HL) was prepared by the condensation reaction of 3-hydroxy-2-naphthoic hydrazide with di-2-pyridyl ketone. Ligand (HL) and its transition metal complexes [CuL2] (1), have been characterized by elemental analysis, FT-IR, UV-Vis., 1H-NMR, and LC–MS techniques. The molecular structure of HL, whose crystal structure could not be obtained, was elucidated by the DFT/B3LYP/6-311+G(d, p) method. The optimized molecular structure, total energy, molecular orbital energy values, molecular electrostatic potential map, reactivity parameters, and interaction with DNA bases were investigated. Theoretical UV-vis spectra of HL were obtained with TD-DFT in different solvent environments. In addition, the ligand and its complex were examined for their antimicrobial activity against pathogenic microorganisms by using a minimal inhibitory concentration method (MIC). It was determined that the [CuL2] (1) complex was generally moderately active. It was also observed that the [CuL2] (1) complex was more active than the HL.
Anahtar Kelimeler
3-hydroxy-2-naphthoic hydrazide | Aroyl hydrazone | Biological activity | Cu(II) complex | DNA bases | Schiff bases
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı ChemistrySelect
Dergi ISSN 2365-6549
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 12-2023
Cilt No 8
Sayı 45
Sayfalar 1 / 9
Doi Numarası 10.1002/slct.202303381
Makale Linki https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202303381