img
High Asymmetric Dimethylarginine ADMA Levels in Patients with Brucellosis        
Yazarlar
Fırat Zafer Mengeloğlu
Abant İzzet Baysal Üniversitesi, Türkiye
Mahmut Sünnetçioğlu
Yüzüncü Yıl Üniversitesi, Türkiye
Mehmet Tosun
Abant İzzet Baysal Üniversitesi, Türkiye
Abdulkadir Küçükbayrak
Abant İzzet Baysal Üniversitesi, Türkiye
Mehmet Reşat Ceylan
Ali İrfan Baran
Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Mustafa Kasım KARAHOCAGİL Prof. Dr. Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye
Hayrettin Akdeniz
Abant İzzet Baysal Üniversitesi, Türkiye
Özet
Asymmetric dimethylarginine (ADMA) is the main endogenous inhibitor of nitric oxide synthase and is considered to be associated with endothelial dysfunction. Brucellosis, a zoonotic disease caused by Brucella spp., can manifest as vasculopathy. The present study was performed to investigate the relationship between ADMA and brucellosis. Serum samples from 39 patients with an accurate diagnosis of brucellosis and from 18 healthy control individuals were included in this study. ADMA levels were significantly higher in the patient group than the controls (P < 0.001). Receiver operating characteristic (ROC) curve analysis indicated that ADMA level a parts per thousand yen0.61 had a sensitivity of 79.5 %, specificity of 88.9 %, positive predictive value of 93.9 %, and negative predictive value of 66.7 %. This is the first report of an association between brucellosis and high levels of ADMA. In conclusion, ADMA levels should be tested in brucellosis cases and that further studies to clarify the mechanism underlying the association between ADMA and brucellosis are required.
Anahtar Kelimeler
ADMA | asymmetric dimethylarginine | Brucella | brucellosis
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı INFLAMMATION
Dergi ISSN 0360-3997
Dergi Tarandığı Indeksler SSCI
Makale Dili İngilizce
Basım Tarihi 02-2014
Cilt No 37
Sayı 1
Sayfalar 127 / 131
Doi Numarası 10.1007/s10753-013-9720-1
Makale Linki http://link.springer.com/10.1007/s10753-013-9720-1