Evaluation of Colistin Ampicillin Sulbactam Combination Efficacy in Imipenem Resistant Acinetobacter baumannii Strains
Yazarlar (5)
Aytekin Çıkman
Mengucek Gazi Training And Research Hospital, Türkiye
Mengucek Gazi Training And Research Hospital, Türkiye
Mehmet Reşat Ceylan Van Yüzüncü Yıl Üniversitesi, Türkiye
Mehmet Parlak Van Education And Research Hospital, Türkiye
Prof. Dr. Mustafa Kasım KARAHOCAGİL Van Yüzüncü Yıl Üniversitesi, Türkiye
Mustafa Berktaş Van Yüzüncü Yıl Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Mikrobiyoloji Bulteni | ||
| Dergi ISSN | 0374-9096 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | MEDLINE/PUBMED, SCOPUS, EMBASE, RESEARCHGATE, GENAMICS, TÜRKİYE ATIF DİZİNİ ve TÜBİTAK/ULAKBİM | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2013 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 47 / 1 / 147–151 | DOI | 10.5578/mb.4523 |
| Makale Linki | http://www.mikrobiyolbul.org/linkout.aspx?pmid=23390912 | ||
| Özet |
| The increasing emergence of multi-drug resistant Acinetobacter baumannii strains as nosocomial pathogens lead to the use of antimicrobial combinations in the treatment of infections due to these bacteria. The aim of this study was to determine the MIC values of colistin and ampicillin/sulbactam and their in vitro synergistic activities by E-test in order to evaluate the effect of this combination against imipenem-resistant A. baumannii isolates. A total of 33 A. baumannii strains isolated from clinical specimens as etiologic agents of nosocomial infections and identified as imipenem-resistant were included in the study. Identification of the isolates was performed by conventional methods and their imipenem resistance was detected with BD Phoenix automated system (Becton Dickinson, USA). MIC values and in vitro synergistic activity of colistin and ampicillin/sulbactam combination were analyzed by E-test (AB Biodisk, Sweden) on Mueller-Hinton agar medium. Synergistic, additive, indifferent and antagonist effects of A. baumannii strains were evaluated by fractional inhibitory concentration (FIC) index. The combination was considered to be synergistic when the FIC index was≤ 0.5, additive when it was 1-> 0.5 and antagonistic when≥ 2. Of the 33 strains included in the study, 21 were resistant to colistin; 30 were resistant and 3 were moderately susceptible to ampicillin/sulbactam. MIC50 and MIC90 values and MIC range of A. baumannii strains for colistin were 8, 32 and 0.13-128 µg/ml; for ampicillin/sulbactam those values were 48, 256 and 12-256 µg/ml, respectively. According to the FIC indices, 15 strains showed synergistic, four additive, five … |
| Anahtar Kelimeler |
| Acinetobacter baumannii | Ampicillin/sulbactam | Colistin | Synergy |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 17 |
| Scopus | 1 |
| Web of Science | 13 |