| Yazarlar |
Rıza Durmaz
Yıldırım Beyazıt Üniversitesi, Türkiye |
|
Mehmet Doğanay
Erciyes Üniversitesi, Türkiye |
|
Mitat Şahin
Kafkas Üniversitesi, Türkiye |
|
Duygu Perçin Renders
Erciyes Üniversitesi, Türkiye |
Prof. Dr. Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Üner Kayabaş
İnönü Üniversitesi, Türkiye |
|
Barış Otlu
İnönü Üniversitesi, Türkiye |
|
Alper Karagöz
|
|
Fatih Büyük
Kafkas Üniversitesi, Türkiye |
|
Özgür Çelebi
Kafkas Üniversitesi, Türkiye |
|
Zülal Öztürk
|
|
Mustafa Ertek
|
|
Mesut Ortatatlı
|
|
Mustafa Zahir Bakıcı
Cumhuriyet Üniversitesi, Türkiye |
|
Selçuk Kılıç
|
|
Sevtap Bostancı
|
|
Ebubekir Ceylan
Ankara Üniversitesi, Türkiye |
|
Ahmet Ayyıldız
|
|
Süleyman Sırrı Kılıç
Fırat Üniversitesi, Türkiye |
| Özet |
| The main perspective of this study was to determine cross-transmissions amongst anthrax cases and provide detailed information regarding the genotypes of Bacillus anthracis isolates circulating in Turkey. A total of 251 B. anthracis isolates were obtained from human (93 isolates), animal (155 isolates), and environmental (three isolates) samples in various provinces of Turkey. All isolates were susceptible to quinolones, vancomycin, tigecycline, and linezolid, but not to ceftriaxone. Excluding human isolates, one of the animal isolates was found to be resistant to penicillin, erythromycin, and doxycycline. Multiple-locus variable-number tandem repeats analysis including 8 loci (MLVA8) revealed 12 genotypes, in which genotype 43 was observed at the highest frequency (41.8 %), followed by genotype 35 (25.5 %) and genotype 27 (10.4 %). Major subtype A3.a was the predominant cluster, including 86.8 % of the isolates. The MLVA25 analysis for the 251 isolates yielded 62 different genotypes, 33 of which had only one isolate, while the remaining 29 genotypes had 2 to 43 isolates, with a total of 218 isolates (86.9 %). These findings indicate very high cross-transmission rates within anthrax cases in Turkey. The genotypes diagnosed in Turkey are populated in the A major cluster. Penicillin prescribed as the first-choice antibiotic for the treatment of anthrax is still effective. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | European Journal of Clinical Microbiology & Infectious Diseases |
| Dergi ISSN | 0934-9723 |
| Dergi Tarandığı Indeksler | SSCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2012 |
| Cilt No | 31 |
| Sayı | 10 |
| Sayfalar | 2783 / 2790 |
| Doi Numarası | 10.1007/s10096-012-1628-4 |
| Makale Linki | http://link.springer.com/10.1007/s10096-012-1628-4 |
| Atıf Sayıları | |
| WoS | 20 |
| SCOPUS | 25 |
| Google Scholar | 51 |
