| Yazarlar |
Prof. Dr. Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye |
Mehmet Aslan
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Mehmet Reşat Ceylan
|
|
Aytekin Çıkman
Erzincan Üniversitesi, Türkiye |
|
Mahmut Sünnetçioğlu
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Mehmet Emin Küçükoğlu
|
|
Abdullah Taşkın
Harran Üniversitesi, Türkiye |
| Özet |
| Objectives: The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis. Design and methods: Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined. Results: Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r = 0.297, p = 0.016) in patients. Conclusions: These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
| Anahtar Kelimeler |
| Acute brucellosis | Atherosclerosis | Catalase activity | Myeloperoxidase activity | Oxidative stress |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CLINICAL BIOCHEMISTRY |
| Dergi ISSN | 0009-9120 |
| Dergi Tarandığı Indeksler | SSCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2012 |
| Cilt No | 45 |
| Sayı | 10 |
| Sayfalar | 733 / 736 |
| Doi Numarası | 10.1016/j.clinbiochem.2012.03.017 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0009912012001452 |
| Atıf Sayıları | |
| WoS | 16 |
| SCOPUS | 14 |
| Google Scholar | 23 |
