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Naturally Occurring Cutaneous Anthrax Antibiotic Treatment and Outcome        
Yazarlar
Üner Kayabaş
İnönü Üniversitesi, Türkiye
Prof. Dr. Mustafa Kasım KARAHOCAGİL Prof. Dr. Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye
Zülal Özkurt
Atatürk Üniversitesi, Türkiye
Gökhan Metan
Hacettepe Üniversitesi, Türkiye
Emine Parlak
Atatürk Üniversitesi, Türkiye
Yaşar Bayındır
İnönü Üniversitesi, Türkiye
Ahmet Kalkan
Karadeniz Teknik Üniversitesi, Türkiye
Hayrettin Akdeniz
Abant İzzet Baysal Üniversitesi, Türkiye
Mehmet Parlak
Atatürk Üniversitesi, Türkiye
Ajh Simpson
Mehmet Doğanay
Erciyes Üniversitesi, Türkiye
Özet
Objectives: Cutaneous anthrax (CA) is the most common clinical presentation in human anthrax, but the duration of antibiotic therapy in naturally occurring CA is controversial. The aim of this study was to compare the clinical outcomes of patients receiving antibiotic treatment for either 3-5 days (group 1) or 7-10 days (group 2) in uncomplicated CA. Methods: A total of 66 patients were enrolled; 29 (44%) in group 1 and 37 (56%) in group 2. Infections were classified as mild (n = 22, 33%) or severe (n = 44, 67%) CA. Results: There were no significant differences between the groups in symptom resolution time, fever clearance time, healing of lesions, development and healing of eschars, requirement for surgical intervention or the development of complications. Both edema resolution time and duration of hospital stay were longer in group 2. There were no therapeutic failures, relapses or deaths in either group. Steroid therapy was used in 32% of patients with severe CA, but a beneficial effect on resolution of edema was not demonstrated. Conclusions: These results suggest that short-course antibiotic therapy is as effective as standard-duration therapy in uncomplicated CA and that steroid therapy may not be effective. Copyright (C) 2012 S. Karger AG, Basel
Anahtar Kelimeler
Anthrax | Antimicrobial therapy | Bacillus anthracis | Bacterial infection | Cutaneous anthrax | Gram-positive bacteria
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı CHEMOTHERAPY
Dergi ISSN 0009-3157
Dergi Tarandığı Indeksler SSCI
Makale Dili İngilizce
Basım Tarihi 01-2012
Cilt No 58
Sayı 1
Sayfalar 34 / 43
Doi Numarası 10.1159/000335593
Makale Linki http://www.karger.com/doi/10.1159/000335593