| Yazarlar |
Rahmet Guner
|
Mustafa Kasım KARAHOCAGİL
Kırşehir Ahi Evran Üniversitesi |
|
Mehmet Buyukberber
|
|
Ozlem Kandemir
|
|
Onur Ural
|
|
Gaye Usluer
|
|
Dilara Inan
|
|
Iftihar Koksal
|
|
Nurcan Baykam
|
|
Kenan Hizel
|
|
Tansu Yamazhan
|
|
Saban Esen
|
|
Mehmet A. Tasyaran
|
| Özet |
| Objective The aim of this study was to demonstrate the relation between intrahepatic (IH) hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) levels and the other HBV replicative intermediates and hepatocyte expression of HBV antigens. Patients and methods Patients with hepatitis B surface antigen (HBsAg) positivity, hepatitis B early antigen negativity, serum HBV DNA levels 10(4) copies/ml or more, and constantly or intermittently increased alanine aminotransferase levels were included. Results Fifty-nine patients were included. There was a good correlation between the levels of IH HBV cccDNA and serum HBV DNA (P<0.001). Serum HBsAg levels were weakly correlated with IH HBV cccDNA levels and moderately correlated with serum HBV DNA (r=0.322, P=0.017; r=0.489, P=0.001, respectively). There were no significant correlation between serum HBsAg level and histologic activity index groups (P=0.691), but stage 0, 1, and greater than 2 fibrosis groups were positively correlated with serum HBsAg levels (P=0.019). IH cccDNA and serum HBV DNA were significantly different in hepatitis B core antigen staining groups (P=0.008 and <0.001, respectively) but there was no significant correlation between HBsAg staining groups and HBV replication markers. There was a weak correlation between serum HBsAg levels and IH HBsAg and hepatitis B core antigen levels (r=0.333, P=0.012; r=0.366, P=0.006, respectively). In multivariate analysis, alanine aminotransferase, age, fibrosis stage, and serum HBsAg quantitation were the most important factors predicting IH HBV cccDNA level. Conclusion Histopathologic damage, serum HBV DNA levels, and IH HBV replication markers have a more complex and dynamic process. However, both serum and IH HBV replication markers provide important knowledge about the activity of the disease. Eur J Gastroenterol Hepatol 23:1185-1191 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Anahtar Kelimeler |
| hepatitis B core antigen | hepatitis B early antigen-negative chronic hepatitis | hepatitis B surface antigen | hepatitis B virus | hepatitis B virus covalently closed circular DNA | immunohistochemistry | quantitative hepatitis B surface antigen |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY |
| Dergi ISSN | 0954-691X |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2011 |
| Cilt No | 23 |
| Sayı | 12 |
| Sayfalar | 1185 / 1191 |
| Doi Numarası | 10.1097/MEG.0b013e32834ba13a |
| Makale Linki | http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00042737-201112000-00014 |
| Atıf Sayıları | |
| WoS | 22 |
| SCOPUS | 23 |
| Google Scholar | 42 |
