img
Serum paraoxonase and arylesterase activities and oxidant status in patients with brucellosis      
Yazarlar
Hasan Karsen
Harran Üniversitesi, Türkiye
Prof. Dr. Mustafa Kasım KARAHOCAGİL Prof. Dr. Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye
Hayrettin Akdeniz
Abant İzzet Baysal Üniversitesi, Türkiye
Mehmet Reşat Ceylan
İrfan Binici
Harran Üniversitesi, Türkiye
Şahbettin Selek
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Hakim Çelik
Harran Üniversitesi, Türkiye
Özet
The aim of this study was to the investigate the effect of brucellosis infection on paraoxonase-1 (PON1) activity and oxidative status in patients with brucellosis. Sixty patients with brucellosis (47 acute, 13 subacute) and the 67 healthy controls were used in the study. Serum PON1 and arylesterase activities, total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), total free sulfhydryl (-SH), and lipid hydroperoxide (LOOH) groups were determined. In addition, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) were measured. Serum PON1 and arylesterase activities, total -SH group levels and TAC were significantly lower in brucellosis patients than controls (P<0.001). TOS, OSI and LOOH levels were significantly higher in brucellosis patients than controls (P<0.001). There were no significant differences between of serum LDL-C, TG and TC levels of patients subjects compared to controls (P > 0.05). Patients with brucellosis are exposed to potent oxidative stress and they have decreased PON1 activity. These predisposal factors might play a role in the pathogenesis for atherosclerosis in patients with brucellosis.
Anahtar Kelimeler
Brucellosis | PON1 activity | oxidative status | atherosclerosis
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
Dergi ISSN 1996-0808
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 07-2011
Cilt No 5
Sayı 13
Sayfalar 1701 / 1706
Doi Numarası 10.5897/AJMR11.438
Makale Linki http://www.academicjournals.org/ajmr/abstracts/abstracts/abstract%202011/4July/Karsen%20et%20al.htm