Serum paraoxonase and arylesterase activities and oxidant status in patients with brucellosis
Yazarlar (7)
Hasan Karsen
Harran Üniversitesi, Türkiye
Harran Üniversitesi, Türkiye
Prof. Dr. Mustafa Kasım KARAHOCAGİL Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Hayrettin Akdeniz Abant İzzet Baysal Üniversitesi, Türkiye
Mehmet Reşat Ceylan
Doç. Dr. İrfan Binici Harran Üniversitesi, Türkiye
Prof. Dr. Şahbettin Selek Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Hakim Çelik Harran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | ||
| Dergi ISSN | 1996-0808 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2011 |
| Cilt / Sayı / Sayfa | 5 / 13 / 1701–1706 | DOI | 10.5897/AJMR11.438 |
| Makale Linki | http://www.academicjournals.org/ajmr/abstracts/abstracts/abstract%202011/4July/Karsen%20et%20al.htm | ||
| UAK Araştırma Alanları |
Tıbbi Mikrobiyoloji
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| Özet |
| The aim of this study was to the investigate the effect of brucellosis infection on paraoxonase-1 (PON1) activity and oxidative status in patients with brucellosis. Sixty patients with brucellosis (47 acute, 13 subacute) and the 67 healthy controls were used in the study. Serum PON1 and arylesterase activities, total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), total free sulfhydryl (-SH), and lipid hydroperoxide (LOOH) groups were determined. In addition, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) were measured. Serum PON1 and arylesterase activities, total-SH group levels and TAC were significantly lower in brucellosis patients than controls (P 0.05). Patients with brucellosis are exposed to potent oxidative stress and they have decreased PON1 activity. These predisposal factors might play a role in the pathogenesis for atherosclerosis in patients with brucellosis. |
| Anahtar Kelimeler |
| Brucellosis | PON1 activity | oxidative status | atherosclerosis |
BM Sürdürülebilir Kalkınma Amaçları
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| Web of Science | 5 |
| Google Scholar | 8 |