| Yazarlar |
İlker İnanç Balkan
|
|
Ayşe Batırel
|
|
Oğuz Karabay
Sakarya Üniversitesi, Türkiye |
|
Canan Ağalar
|
|
Şerife Akalın
Pamukkale Üniversitesi, Türkiye |
|
Özlem Alıcı
|
|
Emine Alp Meşe
Erciyes Üniversitesi, Türkiye |
|
Fatma Aybala Altay
|
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Nilgün Altın
|
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Ferhat Arslan
İstanbul Medipol Üniversitesi, Türkiye |
|
Turan Aslan
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Gülnaz Nural Bekiroğlu
Marmara Üniversitesi, Türkiye |
|
Salih Cesur
|
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Aygül Doğan Çelik
|
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Mustafa Doğan
Namık Kemal Üniversitesi, Türkiye |
|
Bülent Durdu
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Fazilet Duygu
Gaziosmanpaşa Üniversitesi, Türkiye |
|
Aynur Engin
Cumhuriyet Üniversitesi, Türkiye |
|
Derya Öztürk Engin
|
|
İbak Gönen
Süleyman Demirel Üniversitesi, Türkiye |
|
Ertuğrul Güçlü
Sakarya Üniversitesi, Türkiye |
|
Tümer Güven
Yıldırım Beyazıt Üniversitesi, Türkiye |
|
Çiğdem Ataman Hatipoğlu
|
|
Salih Hoşoğlu
Fatih Üniversitesi, Türkiye |
Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Ayşegül Ulu Kılıç
Erciyes Üniversitesi, Türkiye |
|
Bahar Örmen
|
|
Davut Özdemir
Düzce Üniversitesi, Türkiye |
|
Özer Serdar
|
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Nefise Öztoprak
|
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Nurbanu Sezak
|
|
Vedat Turhan
Gülhane Askeri Tıp Akademisi, Türkiye |
|
Nesrin Türker
|
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Havva Yılmaz
|
| Özet |
| Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality. |
| Anahtar Kelimeler |
| Blood stream infection | Colistin | Monotherapy | Multi drug resistant Acinetobacter spp. |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INDIAN JOURNAL OF PHARMACOLOGY |
| Dergi ISSN | 0253-7613 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 47 |
| Sayı | 1 |
| Sayfalar | 95 / 100 |
| Doi Numarası | 10.4103/0253-7613.150383 |
| Makale Linki | http://www.ijp-online.com/text.asp?2015/47/1/95/150383 |
| Atıf Sayıları | |
| WoS | 7 |
| SCOPUS | 8 |
| Google Scholar | 10 |
