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Comparison of colistin monotherapy and non colistin combinations in the treatment of multi drug resistant Acinetobacter spp bloodstream infections A Multicenter retrospective analysis        
Yazarlar
İlker İnanç Balkan
Ayşe Batırel
Oğuz Karabay
Sakarya Üniversitesi, Türkiye
Canan Ağalar
Şerife Akalın
Pamukkale Üniversitesi, Türkiye
Özlem Alıcı
Emine Alp Meşe
Erciyes Üniversitesi, Türkiye
Fatma Aybala Altay
Nilgün Altın
Ferhat Arslan
İstanbul Medipol Üniversitesi, Türkiye
Turan Aslan
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Gülnaz Nural Bekiroğlu
Marmara Üniversitesi, Türkiye
Salih Cesur
Aygül Doğan Çelik
Mustafa Doğan
Namık Kemal Üniversitesi, Türkiye
Bülent Durdu
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Fazilet Duygu
Gaziosmanpaşa Üniversitesi, Türkiye
Aynur Engin
Cumhuriyet Üniversitesi, Türkiye
Derya Öztürk Engin
İbak Gönen
Süleyman Demirel Üniversitesi, Türkiye
Ertuğrul Güçlü
Sakarya Üniversitesi, Türkiye
Tümer Güven
Yıldırım Beyazıt Üniversitesi, Türkiye
Çiğdem Ataman Hatipoğlu
Salih Hoşoğlu
Fatih Üniversitesi, Türkiye
Prof. Dr. Mustafa Kasım KARAHOCAGİL Prof. Dr. Mustafa Kasım KARAHOCAGİL
Yüzüncü Yıl Üniversitesi, Türkiye
Ayşegül Ulu Kılıç
Erciyes Üniversitesi, Türkiye
Bahar Örmen
Davut Özdemir
Düzce Üniversitesi, Türkiye
Özer Serdar
Nefise Öztoprak
Nurbanu Sezak
Vedat Turhan
Gülhane Askeri Tıp Akademisi, Türkiye
Nesrin Türker
Havva Yılmaz
Özet
Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.
Anahtar Kelimeler
Blood stream infection | Colistin | Monotherapy | Multi drug resistant Acinetobacter spp.
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı INDIAN JOURNAL OF PHARMACOLOGY
Dergi ISSN 0253-7613
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-2015
Cilt No 47
Sayı 1
Sayfalar 95 / 100
Doi Numarası 10.4103/0253-7613.150383
Makale Linki http://www.ijp-online.com/text.asp?2015/47/1/95/150383