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Brucellosis in pregnancy: results of multicenter ID-IRI study        
Yazarlar
Asuman İnan
Hakan Erdem
Türkiye
Nazif Elaldı
Sivas Cumhuriyet Üniversitesi, Türkiye
Serda Gulsun
Prof. Dr. Mustafa Kasım KARAHOCAGİL Prof. Dr. Mustafa Kasım KARAHOCAGİL
Türkiye
Abdullah U Pekok
Mehmet Ulug
Recep Tekin
Dicle Üniversitesi, Türkiye
Mile Bosilkovski
Safak Kaya
Asli Haykir-Solay
Tuna Demirdal
İzmir Katip Çelebi Üniversitesi, Türkiye
Selcuk Kaya
Mahmut Sunnetcioglu
Alper Şener
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Selma Tosun
Emsal Aydın
Türkiye
Serap Ural
Tansu Yamazhan
Ege Üniversitesi, Türkiye
Murat Muhçu
Ergin Ayaslioglu
Seval Bilgic-Atli
Ayşe Erbay
Yozgat Bozok Üniversitesi, Türkiye
Pinar Ergen
Ayten Kadanalı
Sağlık Bilimleri Üniversitesi, Türkiye
Suzan Sahin
Elif Sahin-Horasan
Ali Avci
Yakup Cag
Nicholas J Beeching
Özet
Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p<0.001), vaginal bleeding (p<0.001), anemia (blood hemoglobin <11g/dL; p<0.001), high level of serum aspartate aminotransferase (>41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
Anahtar Kelimeler
Abortus | Brucellosis | Intrauterine fetal demise | Obstetrics | Pregnancy | Risk factors
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Dergi ISSN 0934-9723
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 07-2019
Cilt No 38
Sayı 7
Sayfalar 1261 / 1268
Doi Numarası 10.1007/s10096-019-03540-z
Makale Linki http://link.springer.com/10.1007/s10096-019-03540-z
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 14
SCOPUS 15
Google Scholar 28
Brucellosis in pregnancy: results of multicenter ID-IRI study

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