| Yazarlar |
Asuman İnan
|
|
Hakan Erdem
Türkiye |
|
Nazif Elaldı
Sivas Cumhuriyet Üniversitesi, Türkiye |
|
Serda Gulsun
|
Prof. Dr. Mustafa Kasım KARAHOCAGİL
Türkiye |
|
Abdullah U Pekok
|
|
Mehmet Ulug
|
|
Recep Tekin
Dicle Üniversitesi, Türkiye |
|
Mile Bosilkovski
|
|
Safak Kaya
|
|
Asli Haykir-Solay
|
|
Tuna Demirdal
İzmir Katip Çelebi Üniversitesi, Türkiye |
|
Selcuk Kaya
|
|
Mahmut Sunnetcioglu
|
|
Alper Şener
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Selma Tosun
|
|
Emsal Aydın
Türkiye |
|
Serap Ural
|
|
Tansu Yamazhan
Ege Üniversitesi, Türkiye |
|
Murat Muhçu
|
|
Ergin Ayaslioglu
|
|
Seval Bilgic-Atli
|
|
Ayşe Erbay
Yozgat Bozok Üniversitesi, Türkiye |
|
Pinar Ergen
|
|
Ayten Kadanalı
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Suzan Sahin
|
|
Elif Sahin-Horasan
|
|
Ali Avci
|
|
Yakup Cag
|
|
Nicholas J Beeching
|
| Özet |
| Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p<0.001), vaginal bleeding (p<0.001), anemia (blood hemoglobin <11g/dL; p<0.001), high level of serum aspartate aminotransferase (>41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area. |
| Anahtar Kelimeler |
| Pregnancy, Brucellosis, Obstetrics, Abortus, Intrauterine fetal demise, Risk factors |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | European Journal of Clinical Microbiology Infectious Diseases |
| Dergi ISSN | 0934-9723 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2019 |
| Cilt No | 38 |
| Sayı | 7 |
| Sayfalar | 1261 / 1268 |
| Doi Numarası | 10.1007/s10096-019-03540-z |
| Makale Linki | http://link.springer.com/10.1007/s10096-019-03540-z |
| Atıf Sayıları | |
| WoS | 12 |
| SCOPUS | 14 |
| Google Scholar | 25 |
