| Yazarlar |
Büşra Cebeci Koncuk
|
Doç. Dr. Zuhal ALIM
Ahi Evran Üniversitesi, Türkiye |
|
Şükrü Beydemir
Atatürk Üniversitesi, Türkiye |
| Özet |
| The organophosphate target enzyme paraoxonase-1 (PON1) has been extensively studied in toxicology. Pesticides are organophosphate compounds that are commonly used in agriculture. They are also used as nerve gases, such as sarin and soman. Therefore, the effects of these compounds on enzymatic activity are well known. In the present study, we investigated the in vitro effects of fenoxaprop-p-ethyl, lambda cyhalothrin, imidacloprid, and dichlorvos pesticides on sheep liver microsomal PON1. The enzyme was purified approximately 141-fold with a specific activity of 1822.22 EU/mg proteins. The pesticides inhibited sheep liver PON1 in vitro, and the IC 50 values for these compounds were 0.0103, 0.069, 0.157, and 0.2 μ M, respectively. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF CHEMISTRY |
| Dergi ISSN | 1300-0527 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2014 |
| Cilt No | 38 |
| Sayfalar | 512 / 520 |
| Doi Numarası | 10.3906/kim-1308-20 |
| Makale Linki | http://journals.tubitak.gov.tr/chem/issues/kim-14-38-3/kim-38-3-16-1308-20.pdf |
| Atıf Sayıları | |
| TRDizin | 5 |
