VITAMIN D DEFICIENCY AND CLINICAL SEVERITY OF COVID-19 INFECTION
Yazarlar (6)
Doç. Dr. Hasan Esat YÜCEL Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Zeynel Abidin ERBESLER Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Kağan TUR Kırşehir Ahi Evran Üniversitesi, Türkiye
Mesut Çeliker
T.C. Sağlık Bakanlığı, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Doç. Dr. Naime Meriç Konar Türkiye
Dr. Öğr. Üyesi Cahit Uçar Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | Annals of Medical Research | ||
| Dergi ISSN | 2636-7688 | ||
| Dergi Tarandığı Indeksler | DRJI, EBSCO | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 29 / 2 / 134–138 | DOI | 10.5455/annalsmedres.2021.04.360 |
| Makale Linki | http://dx.doi.org/10.5455/annalsmedres.2021.04.360 | ||
| UAK Araştırma Alanları |
Anesteziyoloji ve Reanimasyon
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| Özet |
| Aim: Pancreatic ductal adenocarcinoma (PDAC) has high mortality and early stage metastatic potential. Thus, the developing new clinical approach and metastasis blocking strategy-based drugs are essential for cure of PDAC. In this study we aimed to investigate the effects of cell surface transmembrane glycoprotein CD44 on the regulation of key ECM proteins, integrin β1, fibronectin and collagen IV, in Panc-1 and MiaPaCa-2 cells.Material and Methods: Followed by cell viability assay using MTS, fibronectin and collagen IV protein expression levels and integrin β1 mRNA level were analyzed in Panc-1 and MiaPaCa-2 cells treated with 50 nM negative siRNA and CD44 siRNA for 72 h using western blot and RT-PCR, respectively.Results: Based on our findings, the downregulation of CD44 using specific siRNA led to decrease fibronectin and collagen IV proteins expressions, and also Integrin β1 mRNA expression in both Panc-1 and MiaPaCa-2 cell lines.Conclusion: CD44 siRNA based therapies have effective role to inhibit ECM degradation in PDAC progression. CD44 is also promising target for against PDAC through inhibiting migration, invasion and metastasis steps. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |