img
img
The effect of edaravone on ischemia reperfusion injury in rat ovary     
Yazarlar (5)
Prof. Dr. Mustafa KARA Prof. Dr. Mustafa KARA
Bozok Üniversitesi, Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Çukurova Üniversitesi, Türkiye
Kuyucu Yurdun
Abdullah Tuli
Çukurova Üniversitesi, Türkiye
Özgül Tap
Çukurova Üniversitesi, Türkiye
Devamını Göster
Özet
The aim of this study was to investigate the effect of edaravone on experimentally induced ovarian torsion/detorsion ischemia/reperfusion (I/R) injury. Forty-six female adult Wistar-Albino rats were utilized to create five groups: In group 1, only 5 mg/kg edaravone was given and ovary torsion was not performed. In group 2, torsion was not performed and no drug was given. In group 3, vehicle was given and torsion/detorsion was performed. In group 4, 1 mg/kg edaravone was given and torsion/detorsion was performed. In group 5, edaravone; 5 mg/kg drug was administered and torsion/detorsion was performed. Right ovarian torsion was simulated for a 3-h period of ischemia and a 1-h reperfusion period. Right ovaries were then surgically extirpated in all groups. In ovarian tissue samples malondialdehyde (MDA) levels and activity of superoxide dismutase were studied. Microscopic ovarian tissue damage was scored by histologic and electron microscopic findings. The MDA level in the group 5 was significantly lower than group 3 (p<0.001). Superoxide dismutase activity in the group 5 was significantly higher than group 3 (p<0.001). Histopathological ovarian tissue damage in the group 5 were significantly lower than group 3 (p<0.001). These results indicate that edaravone could be an effective agent in the short-term treatment and prevention of ovarian ischemia and reperfusion damage.
Anahtar Kelimeler
Edaravone | Ovarian torsion | Rat torsion model | Ischemia-reperfusion
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Dergi ISSN 0301-2115 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-2012
Cilt No 162
Sayı 2
Sayfalar 197 / 202
Doi Numarası 10.1016/j.ejogrb.2012.02.026
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 24
Google Scholar 59
The effect of edaravone on ischemia reperfusion injury in rat ovary

Paylaş