Effects of caffeine on neuronal apoptosis in neonatal hypoxic ischemicbrain injury
Yazarlar (4)
Hasan Kılıçdağ
Acıbadem Üniversitesi, Türkiye
Acıbadem Üniversitesi, Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU Çukurova Üniversitesi, Türkiye
Suzan Zorludemir
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Şeyda Erdoğan Çukurova Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | ||
| Dergi ISSN | 1476-7058 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2014 |
| Cilt / Sayı / Sayfa | 27 / 14 / 1470–1475 | DOI | 10.3109/14767058.2013.878694 |
| Özet |
| Objective: Hypoxia-ischemia (HI) in rat pups leads to strong activation of apoptosis, and apoptosis contributes significantly to cerebral damage in the perinatal period. Caffeine displays a broad array of actions on the brain. The aim of this study was to investigate the effects of caffeine on neuronal apoptosis in a hypoxic-ischemic neonatal model.Methods: Twenty-four seven-day-old Wistar rat pups were subjected to right common carotid artery ligation and hypoxia for 2 h. Sham group (n = 8) had a median neck incision, but the rats were not subjected to ligation or hypoxia. The pups were treated with 20 mg/kg/day caffeine citrate (n = 8) or saline (n = 8) immediately before HI and at 0, 24, 48 and 72 h post-hypoxia. Neuronal apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) and caspase-3 in the hippocampus and parietal cortex of both hemispheres … |
| Anahtar Kelimeler |
| Apoptosis | brain injury | caffeine | hypoxia | ischemia |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 68 |
| Web of Science | 41 |