| Yazarlar (4) |
Tufan Mert
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye |
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Çukurova Üniversitesi, Türkiye |
|
İsmail Günay
Çukurova Üniversitesi, Türkiye |
|
Cemil Göçmen
Çukurova Üniversitesi, Türkiye |
| Özet |
| The conduction of action potential in peripheral nerves requires the coordinated opening and closing of Na(+) and K(+) channels. In the present study, we used the sucrose-gap recording technique to determine the electrophysiological changes of the regenerating nerves after sciatic nerve injury by using 4-aminopyridine (4-AP) and tetraethylammonium (TEA), and lidocaine. 4-AP enhanced the amplitude and duration of the compound action potentials (CAPs) of regenerating sciatic nerve 15 days post crush (15 dpc), and elicited delayed depolarizations (Del-dep) in 38 dpc and intact groups. Hyperpolarizing afterpotentials elicited by 4-AP were completely removed by TEA in both 15 and 38 dpc. Lidocaine effectively blocked the CAP amplitude. This blockage was more pronounced in 15 dpc than 38 dpc. This agent also exhibited a partial blockage on the Del-dep amplitude. These results may indicate that the changes in the activities of 4-AP- and TEA-sensitive K(+) channels and slow Na(+) channels may play critical roles in nerve excitability and conduction. |
| Anahtar Kelimeler |
| crush injury | regeneration | delayed depolarization | 4-aminopyridine | lidocaine |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | NEUROSCIENCE LETTERS |
| Dergi ISSN | 0304-3940 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2004 |
| Cilt No | 363 |
| Sayı | 3 |
| Sayfalar | 212 / 217 |
| Doi Numarası | 10.1016/j.neulet.2004.03.018 |
| Atıf Sayıları | |
| WoS | 15 |
| Google Scholar | 25 |
