| Yazarlar (8) |
Hasan Kılıçdağ
Acıbadem Üniversitesi, Türkiye |
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Çukurova Üniversitesi, Türkiye |
|
Leman Sencar
Çukurova Üniversitesi, Türkiye |
|
Şeyda Erdoğan
Çukurova Üniversitesi, Türkiye |
|
Şeyda Erdoğan
Çukurova Üniversitesi, Türkiye |
|
Suzan Zorludemir
Çukurova Üniversitesi, Türkiye |
|
Sait Polat
Çukurova Üniversitesi, Türkiye |
|
Gülfidan Coşkun
Çukurova Üniversitesi, Türkiye |
| Özet |
| Necrotizing enterocolitis has been investigated and debated extensively in recent years; however, there is still no effective treatment. The aim of this study was thus to examine the effects of β-estradiol on intestinal injury in rats. Twenty-four newborn female rat pups were divided into three groups. In group 1 (sham), hypoxia-re-oxygenation was not performed. In group 2 (saline), the rats were injected with saline after hypoxia-re-oxygenation, and the process was repeated for 5 d. In group 3 (β-estradiol treatment), the rats were subjected to hypoxia-re-oxygenation and then given β-estradiol intraperitoneally once a day for 5 d. After these procedures, the terminal ileum was removed for analysis. Statistically significant differences in histological grades were found between groups 1 and 2 (p = 0.000), groups 1 and 3 (p = 0.028), and groups 2 and 3 (p = 0.021). There were also differences in TNF-α and IL-6 levels between groups 2 and 3 (p = 0.000 and p = 0.038, respectively) and between groups 1 and 2 (p = 0.000 and p = 0.000); there was no difference between groups 1 and 3 (p = 0.574 and p = 0.195, respectively). Electron microscopy examination revealed a decrease in lipid droplets at the apical cytoplasm of the columnar cells in group 2; in group 3, the absorption of the lipids as lipid droplets was similar to that of group 1. In this study, β-estradiol was found to decrease the intensity of intestinal injury significantly by inhibiting TNF-α and IL-6. |
| Anahtar Kelimeler |
| -Estradiol | IL-6 | intestinal injury | necrotizing enterocolitis | newborn rat | TNF- |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | The Journal of Maternal-Fetal & Neonatal Medicine |
| Dergi ISSN | 1476-7058 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2015 |
| Cilt No | 29 |
| Sayı | 12 |
| Sayfalar | 1935 / 1940 |
| Doi Numarası | 10.3109/14767058.2015.1068286 |
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 2 |
