Impacts of estradiol on intestinal injury in newborn rats
Yazarlar (8)
Hasan Kılıçdağ
Acıbadem Üniversitesi, Türkiye
Acıbadem Üniversitesi, Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU Çukurova Üniversitesi, Türkiye
Leman Sencar Çukurova Üniversitesi, Türkiye
Şeyda Erdoğan Çukurova Üniversitesi, Türkiye
Şeyda Erdoğan Çukurova Üniversitesi, Türkiye
Suzan Zorludemir
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Sait Polat Çukurova Üniversitesi, Türkiye
Gülfidan Coşkun Çukurova Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | The Journal of Maternal-Fetal & Neonatal Medicine | ||
| Dergi ISSN | 1476-7058 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2015 |
| Cilt / Sayı / Sayfa | 29 / 12 / 1935–1940 | DOI | 10.3109/14767058.2015.1068286 |
| Özet |
| Objective: Necrotizing enterocolitis has been investigated and debated extensively in recent years; however, there is still no effective treatment. The aim of this study was thus to examine the effects of β-estradiol on intestinal injury in rats.Methods: Twenty-four newborn female rat pups were divided into three groups. In group 1 (sham), hypoxia–re-oxygenation was not performed. In group 2 (saline), the rats were injected with saline after hypoxia–re-oxygenation, and the process was repeated for 5 d. In group 3 (β-estradiol treatment), the rats were subjected to hypoxia–re-oxygenation and then given β-estradiol intraperitoneally once a day for 5 d. After these procedures, the terminal ileum was removed for analysis.Results: Statistically significant differences in histological grades were found between groups 1 and 2 (p = 0.000), groups 1 and 3 (p = 0.028), and groups 2 and 3 (p = 0.021). There were also … |
| Anahtar Kelimeler |
| -Estradiol | IL-6 | intestinal injury | necrotizing enterocolitis | newborn rat | TNF- |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |
| Web of Science | 1 |