The protective role of jervine against radiation-induced gastrointestinal toxicity
Yazarlar (9)
Selvinaz Yakan
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Tuba Aydın
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Canan Gülmez
Iğdır Üniversitesi, Türkiye
Özkan Özden
Kafkas Üniversitesi, Türkiye
Kıvılcım Eren Erdoğan
Çukurova Üniversitesi, Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Çukurova Üniversitesi, Türkiye
Fundagül Andiç
Çukurova Üniversitesi, Türkiye
Onur Atakişi
Kafkas Üniversitesi, Türkiye
Ahmet Çakır
Kilis 7 Aralık Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Q1) | ||
| Dergi ISSN | 1475-6366 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 34 / 1 / 789–798 | DOI | 10.1080/14756366.2019.1586681 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1586681 | ||
| Özet |
| In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT. |
| Anahtar Kelimeler |
| Radiotherapy | jervine | pyruvate dehydrogenase (PDH) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 8 |
| Google Scholar | 10 |