| Yazarlar |
Nermin Tanık
Bozok Üniversitesi, Türkiye |
|
Halilibrahim Serin
Bozok Üniversitesi, Türkiye |
Prof. Dr. Asuman ÇELİKBİLEK
Bozok Üniversitesi, Türkiye |
|
Levent Ertuğrul İnan
Bozok Üniversitesi, Türkiye |
|
Fatma Gündoğdu
Bozok Üniversitesi, Türkiye |
| Özet |
| Parkinson's disease (PD) is a neurodegenerative disorder characterized by hyposmia in the preclinical stages. We investigated the relationships of olfactory bulb (OB) volume and olfactory sulcus (OS) depth with basal ganglia and hippocampal volumes. The study included 25 patients with PD and 40 age- and sex-matched control subjects. Idiopathic PD was diagnosed according to published diagnostic criteria. The Hoehn and Yahr (HY) scale, the motor subscale of the Unified Parkinson's Disease Rating Scale (UPDRS III), and the Mini-Mental State Examination (MMSE) were administered to participants. Volumetric measurements of olfactory structures, the basal ganglia, and hippocampus were performed using magnetic resonance imaging (MRI). OB volume and OS depth were significantly reduced in PD patients compared to healthy control subjects (p < 0.001 and p < 0.001, respectively). The OB and left putamen volumes were significantly correlated (p = 0.048), and the depth of the right OS was significantly correlated with right hippocampal volume (p = 0.018). We found significant correlations between OB and putamen volumes and OS depth and hippocampal volume. Our study is the first to demonstrate associations of olfactory structures with the putamen and hippocampus using MRI volumetric measurements. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| Anahtar Kelimeler |
| Parkinson's disease, Olfactory bulb, Olfactory sulcus depth, Putamen, Hippocampus |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Neuroscience Letters |
| Dergi ISSN | 0304-3940 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2016 |
| Cilt No | 620 |
| Sayfalar | 111 / 114 |
| Doi Numarası | 10.1016/j.neulet.2016.03.050 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0304394016301963 |
| Atıf Sayıları | |
| WoS | 23 |
