Effects of Theranekron and alpha-lipoic acid combined treatment on GAP-43 and Krox-20 gene expressions and inflammation markers in peripheral nerve injury
Yazarlar (10)
Doç. Dr. Leman Sencar Cukurova University, Türkiye
Dr. Öğr. Üyesi Gülfidan Coşkun Cukurova University, Türkiye
Arş. Gör. Dilek Şaker Cukurova University, Türkiye
Arş. Gör. Tuğçe Sapmaz Cukurova University, Türkiye
Arş. Gör. Samet Kara Cukurova University, Türkiye
Dr. Öğr. Üyesi Alper Çelenk Cukurova University, Türkiye
Prof. Dr. Sema Polat Cukurova University, Türkiye
Prof. Dr. Derviş Mansuri Yılmaz Cukurova University, Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Sait Polat Çukurova Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ULTRASTRUCTURAL PATHOLOGY (Q4) | ||
| Dergi ISSN | 0191-3123 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2021 |
| Cilt / Sayı / Sayfa | 45 / 3 / 167–181 | DOI | 10.1080/01913123.2021.1923600 |
| Makale Linki | http://dx.doi.org/10.1080/01913123.2021.1923600 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Peripheral nerve injury (PNI) is a major health problem that results in loss of motor and sensory functions. In treatment of PNI, various methods such as anastomosis, nerve grafts, nonneural tissue grafts, and nerve conduits are applied. In the present study, it was aimed to investigate the effects of Theranekron and Alpha-lipoic acid (ALA) combined treatment on nerve healing in experimental PNI by using histomorphometric, electron microscopic, immunohistochemical and molecular biological methods. Sixty-two Wistar rats were divided into six groups; the normal control group, sham operation group, experimental control group having a crush type injury with no treatment, Theranekron treatment group, ALA treatment group and Theranekron+ALA combined treatment group. Sciatic nerve tissue samples were obtained on days 1, 7 and 14 following injury in all groups. GAP-43 expression was upregulated in all PNI … |
| Anahtar Kelimeler |
| Theranekron | Alpha-lipoic acid | Gap-43 | Krox-20 | PNI |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |