Retinol binding protein 4 and hs CRP levels in patients with migraine
Yazarlar (5)
Nermin Tanık Bozok Üniversitesi, Türkiye
Asuman Çelikbilek
Bozok Üniversitesi, Türkiye
Bozok Üniversitesi, Türkiye
Aslı Metin Mahmutoğlu Bozok Üniversitesi, Türkiye
Ayşe Yeşim Göçmen Bozok Üniversitesi, Türkiye
Levent Ertuğrul İnan
Bozok Üniversitesi, Türkiye
Bozok Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Neurological Sciences | ||
| Dergi ISSN | 1590-1874 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2015 |
| Cilt / Sayı / Sayfa | 36 / 10 / 1823–1827 | DOI | 10.1007/s10072-015-2262-6 |
| Makale Linki | http://link.springer.com/10.1007/s10072-015-2262-6 | ||
| Özet |
| Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine. The release of proinflammatory cytokines during migraine results in recurrent sterile neurogenic inflammation. This study aimed to determine the correlation between RBP4 and hs-CRP levels, and migraine, which is considered an inflammatory disease. The study included 48 migraine patients and 40 age- and gender-matched controls. Migraine was diagnosed according to International Classification of Headache Disorders-II. The serum RBP4 level was measured using a commercial ELISA kit and hs-CRP was measured using an enzyme immunoassay test kit. The serum RBP4 level was significantly lower in the migraine patients than in the controls (P < 0.001), whereas the hs-CRP level was significantly higher in the migraine patients (P < 0.001). RBP4 and hs-CRP levels did not differ between the migraine patients with and without aura (P > 0.05). Migraine headache severity, frequency and duration were not correlated with serum RBP or hs-CRP levels (P > 0.05). The observed high hs-CRP level and low RBP4 level in migraine patients suggest that vitamin A might play a major role in the pathogenesis of migraine. It is known that inflammation is a key factor in many diseases. Additional research might result in a better understanding of the anti-inflammatory effects of vitamin A. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 18 |