| Yazarlar |
Prof. Dr. Asuman ÇELİKBİLEK
Bozok Üniversitesi, Türkiye |
Ayşe Yeşim Göçmen
Bozok Üniversitesi, Türkiye |
|
Gökmen Zararsız
Erciyes Üniversitesi, Türkiye |
|
Nermin Tanık
Bozok Üniversitesi, Türkiye |
Prof. Dr. Hakan AK
Bozok Üniversitesi, Türkiye |
|
Elif Börekçi
|
|
Namık Delibaş
Hacettepe Üniversitesi, Türkiye |
| Özet |
| Objectives: Inflammation is proposed to be involved in the pathogenesis of both vitamin D deficiency and migraine. However, the data examining the relation of vitamin D with migraine are limited. We aimed to investigate the serum levels of vitamin D, vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) in combination, in migraine patients from central Anatolia region. Methods: Fifty-two newly diagnosed migraine patients and age-and sex-matched 49 control subjects were enrolled in this cross-sectional prospective study. Migraine diagnosis was settled according to the International Classification of Headache Disorders-II diagnostic criteria. Serum samples were analysed for the measurement of vitamin D, VDBP and VDR levels by using commercial enzyme-linked immuno sorbent assay kits. Results: Serum vitamin D and VDR levels were found to be significantly lower in migraine patients than in controls (p = 0.012 and p = 0.038, respectively); whereas serum VDBP levels were similar between the groups (p > 0.05). There was no correlation between serum vitamin D, VDBP and VDR levels and headache characteristics including aura, attack severity, frequency and duration, and disease duration (p > 0.05). In terms of headache characteristics, no significant difference between migraineurs with vitamin D values < 25 and >= 25 ng/ml was observed (p > 0.05). Conclusions: The present findings may suggest that decreased serum vitamin D levels were associated with migraine. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | International Journal of Clinical Practice |
| Dergi ISSN | 1368-5031 |
| Dergi Tarandığı Indeksler | SSCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2014 |
| Cilt No | 68 |
| Sayı | 10 |
| Sayfalar | 1272 / 1277 |
| Doi Numarası | 10.1111/ijcp.12456 |
| Makale Linki | http://doi.wiley.com/10.1111/ijcp.12456 |
| Atıf Sayıları | |
| WoS | 28 |
