| Yazarlar |
Elif Asik
|
Dr. Öğr. Üyesi Yeliz AKPINAR
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ayşe Caner
Ege Üniversitesi, Türkiye |
|
Nermin Kahraman
|
|
Tulin Guray
|
|
Murvet Volkan
|
|
Constance Albarracin
|
|
Apar Pataer
|
|
Banu Arun
|
|
Bulent Ozpolat
|
| Özet |
| Aim: To investigate the role of EF2K in BRCA1-mutated breast cancer. Materials & methods: We developed silica coated cobalt-ferrite (CoFe) nanoparticles for in vivo delivery of small interfering RNAs (siRNAs) into BRCA1-mutated breast cancer. Results: Expression of EF2K is highly upregulated in themajority (78.5%) of BRCA1-mutated patients and significantly associated with poor patient survival and metastasis. Silencing of EF2K reduced cell proliferation, migration and invasion of the cancer cells. In vivo therapeutic targeting of EF2K by CoFe-siRNA-nanoparticles leads to sustained EF2K gene knockdown and suppressed tumor growth in orthotopic xenograft models of BRCA1-mutated breast cancer. Conclusion: EF2K is a potential novel molecular target in BRCA1-mutated tumors and CoFe-based siRNA nanotherapy may be used as a novel approach to target EF2K. |
| Anahtar Kelimeler |
| angiogenesis, BRCA1, breast cancer, EF2 kinase, gene-silencing therapy, invasion, metastasis, migration, nanoparticles, PARP inhibitor |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Nanomedicine |
| Dergi ISSN | 1743-5889 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2019 |
| Cilt No | 14 |
| Sayı | 17 |
| Sayfalar | 2315 / 2338 |
| Doi Numarası | 10.2217/nnm-2019-0132 |
| Makale Linki | https://www.futuremedicine.com/doi/10.2217/nnm-2019-0132 |
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 15 |
| Google Scholar | 16 |
