DNA-binding, enzyme inhibition, and photochemical properties of chalcone-containing metallophthalocyanine compounds
Yazarlar (3)
Akdeniz Üniversitesi, Türkiye
Prof. Dr. Aslıhan GÜNEL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Sakarya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Bioorganic Chemistry | ||
| Dergi ISSN | 0045-2068 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2018 |
| Cilt / Sayı / Sayfa | 81 / 1 / 71–78 | DOI | 10.1016/j.bioorg.2018.08.002 |
| Makale Linki | http://dx.doi.org/10.1016/j.bioorg.2018.08.002 | ||
| Özet |
| In this study, two novel phthalocyanine complexes were synthesized using their corresponding metal salts and 4-(4-(3-(2,4,5-trimethoxyphenyl)acryloyl)phenoxy)phthalo-nitrile as chalcone ligand (4), which was prepared from the reaction of 4-nitrophthalonitrile with 4-hydroxyphenyl-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (3). These metallophthalocyanines showed good solubility in organic solvents such as CDCl 3 , DCM, THF, DMF, and DMSO. The novel phthalocyanine compounds 4a (Pc-Zn) and 4b (Pc-Co) were characterized using their UV–vis, FT-IR, 1 H NMR, 13 C NMR, and MALDI-TOF mass spectra and elemental analysis. Then the DNA-binding and xanthine oxidase and carbonic anhydrase-I inhibition properties of compounds 4a and 4b were investigated. Photochemical properties (such as singlet oxygen generation and photodegradation) of this novel chalcone phthalocyanine (4a) were determined in dimethyl sulfoxide (DMSO). |
| Anahtar Kelimeler |
| Chalcone | DNA-binding | Enzyme inhibition | Photochemical | Phthalocyanine |
Science Direct
DNA-binding, enzyme inhibition, and photochemical properties of chalcone-containing metallophthalocyanine compounds
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 28 |
| Google Scholar | 33 |