Synthesis and biological evaluation of optically active conjugated and lactone derivatives
Yazarlar (5)
Melis Ardan
Middle East Technical University (Metu), Türkiye
Middle East Technical University (Metu), Türkiye
Serdar Sezer Middle East Technical University (Metu), Türkiye
Prof. Dr. Aslıhan GÜNEL Kırşehir Ahi Evran Üniversitesi, Türkiye
Mahinur Akkaya Middle East Technical University (Metu), Türkiye
Cihangir Tanyeli Middle East Technical University (Metu), Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Bioorganic and Medicinal Chemistry Letters | ||
| Dergi ISSN | 0960-894X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2011 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 22 / 18 / 5814–5818 | DOI | 10.1016/j.bmcl.2012.07.090 |
| Makale Linki | https://hdl.handle.net/11511/41482 | ||
| Özet |
| An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted γ- and δ-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97–99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated. |
| Anahtar Kelimeler |
| Asymmetric synthesis | Enzymatic resolution | Optically active lactones |
Science Direct
Synthesis and biological evaluation of optically active conjugated and lactone derivatives
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 23 |
| Scopus | 4 |