Changes in intracellular protein expression in cortex thalamus and hippocampus in a genetic rat model of absence epilepsy
Yazarlar (7)
Özkan Daniş Marmara Üniversitesi, Türkiye
Serap Demir Marmara Üniversitesi, Türkiye
Prof. Dr. Aslıhan GÜNEL Kırşehir Ahi Evran Üniversitesi, Türkiye
Rezzan Gülhan Aker
Marmara Üniversitesi, Türkiye
Marmara Üniversitesi, Türkiye
Medine Gülçebi
Marmara Üniversitesi, Türkiye
Marmara Üniversitesi, Türkiye
Filiz Onat Marmara Üniversitesi, Türkiye
Ayşe Ogan
Marmara Üniversitesi, Türkiye
Marmara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Brain Research Bulletin | ||
| Dergi ISSN | 0361-9230 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2011 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 84 / 6 / 381–388 | DOI | 10.1016/j.brainresbull.2011.02.002 |
| Özet |
| Epilepsy is a chronic disorder characterized by repeated seizures resulting from abnormal activation of neurons in the brain. Although mutations in genes related to Na+, K+, Ca2+ channels have been defined, few studies show intracellular protein changes. We have used proteomics to investigate the expression of soluble proteins in a genetic rat model of absence epilepsy “Genetic Absence Epilepsy Rats from Strasbourg (GAERS)”. The advantage of this technique is its high throughput quantitative and qualitative detection of all proteins with their post-translational modifications at a given time. The parietal cortex and thalamus, which are the regions responsible for the generation of absence seizures, and the hippocampus, which is not involved in this activity, were dissected from GAERS and from non-epileptic control rat brains. Proteins from each tissue sample were isolated and separated by two-dimensional gel … |
| Anahtar Kelimeler |
| Cortex | Epilepsy | GAERS | Hippocampus | Proteomics | Thalamus |
Science Direct
Changes in intracellular protein expression in cortex thalamus and hippocampus in a genetic rat model of absence epilepsy
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 35 |
| Scopus | 5 |