Synthesis Of Bicyclo 2 2 2 OCTANE 2 3 5 6 7 8 Hexols Bishomoinositols New Glycosidase Inhibitors
Yazarlar (3)
Middle East Technical University (Metu), Türkiye
Prof. Dr. Aslıhan GÜNEL
Sinop Üniversitesi, Türkiye
Middle East Technical University (Metu), Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Organic Chemistry | ||
| Dergi ISSN | 0022-3263 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2008 |
| Cilt / Sayı / Sayfa | 73 / 12 / 4370–4375 | DOI | 10.1021/jo800553u |
| Makale Linki | https://hdl.handle.net/11511/57615 | ||
| Özet |
| (Chemical Equation Presented) For the construction of the bicyclo[2.2.2]octane skeleton, 2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole was reacted with vinylene carbonate to give two isomeric cycloadditon products having the bicyclo[2.2.2]octane skeleton. Hydrolysis of the ketal ring and the opening of the carbonate functionality, followed by hydroxylation of the remaining double bond resulted in the formation of a symmetrical hexol. Epoxidation of the double bond in the cycloaddition products and the subsequent ring-opening reactions produce two additional hexol derivatives. One of the synthesized molecules exhibited enzymespecific inhibition against α-glycosidase. © 2008 American Chemical Society. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 19 |
| Google Scholar | 31 |