| Yazarlar |
İlknur Çiçek
|
Doç. Dr. Turgay TUNÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Suzan Abdurrahmanoğlu
Marmara Üniversitesi, Türkiye |
Prof. Dr. Aslıhan GÜNEL
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| New chiral aminoalcohol-benzimidazole hybrids have been synthesized from commercially available aminoalcohols. [S(+)-Phenylglycinol, S(−)- Phenylalaninol and S(+)- Leuicinol] and 2-(chloromethyl)-N-tosyl-1-H-benzimidazole. The synthesized compound were characterized by IR, NMR, and LC-MS analysis. The antibacterial properties of aminoalcohol-benzimidazole hybrid molecules 4 a, 4 b, and 4 c were investigated against both gram (+ve) and gram (-ve) bacterial pathogens by the well-diffusion method using several standarts. The cell-based biological experiment was consistent with in silico studies. Furthermore, in silico studies revealed that all synthesized compounds could be suggested as potential drugs for inhibition of both peptide deformylase for bacteria and sterol 14α-demethylase for yeast. |
| Anahtar Kelimeler |
| Aminoalcohol | Antibacterial Agent | Benzimidazole | Molecular docking | PDF inhibitor |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ChemistrySelect |
| Dergi ISSN | 2365-6549 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2020 |
| Cilt No | 5 |
| Sayı | 15 |
| Sayfalar | 4650 / 4654 |
| Doi Numarası | 10.1002/slct.202000355 |
| Makale Linki | [{"content-version":"vor","content-type":"application/pdf","intended-application":"text-mining","URL":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fslct.202000355"},{"content-version":"vor","content-type":"application/pdf","intended- |
| Atıf Sayıları | |
| SCOPUS | 9 |
| Google Scholar | 7 |
