Antimony III complexes with 2 amino 4 6 dimethoxypyrimidines Synthesis characterization and biological evaluation
Yazarlar (6)
Doç. Dr. Turgay TUNÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Aydin Adnan Menderes University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Photochemistry and Photobiology B Biology | ||
| Dergi ISSN | 1011-1344 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2015 |
| Cilt / Sayı / Sayfa | 153 / 1 / 206–214 | DOI | 10.1016/j.jphotobiol.2015.09.022 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1011134415003176 | ||
| Özet |
| Novel pyrimidine compound bearing disulfide bridge, 5,5'-disulfanediyIbis(2-amino-4,6-dimetoxypyrimidine) (3) was synthesized by reduction of 2-amino-4,6-dimethoxy-5-thiocyanatopyrimidine for the first time, and its structure was confirmed by X-ray crystallographic analysis. Novel binuclear antimony(III) compound of (3), {Sb[5,5'-disulfanediylbis(2-amino-4,6-dimetoxypyrimidine)]Cl-3}(2) (4) and mononuclear antimony(III) compounds, SbL2O3, [L: 2-amino-5-thioI-4,6-dimethoxy pyrimidine (2) and 2-amino-5-(1H-tetrazol-5-ylthio)-4,6-dimethoxypyrimidine (6)] were synthesized and characterized with the help of elemental analysis, molecular conductivity, FT-IR,H-1-NMR and LC-MS techniques. The geometrical structures optimized by a DFT/B3LYP/LANL2DZ method of the compounds, indicated that monomeric compounds have square pyramidal shape. Both antileishmanial activity against Leishmania tropica promastigote and glutathione reductase inhibitory activity were determined in vitro. The results showed that (3) has the best biological activity. (C) 2015 Elsevier B.V. All rights reserved. |
| Anahtar Kelimeler |
| Antileishmanial activity | Antimony(III) complexes | Glutathione reductase inhibition |
Science Direct
Antimony III complexes with 2 amino 4 6 dimethoxypyrimidines Synthesis characterization and biological evaluation
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 9 |
| Google Scholar | 14 |