| Yazarlar |
Doç. Dr. Turgay TUNÇ
Ahi Evran Üniversitesi, Türkiye |
Mehmet Sayım Karacan
Gazi Üniversitesi, Türkiye |
|
Hatice Ertabaklar
Adnan Menderes Üniversitesi, Türkiye |
|
Nurcan Karacan
Gazi Üniversitesi, Türkiye |
|
Musa Sarı
Gazi Üniversitesi, Türkiye |
|
Orhan Büyükgüngör
Ondokuz Mayıs Üniversitesi, Türkiye |
| Özet |
| Novel pyrimidine compound bearing disulfide bridge, 5,5'-disulfanediyIbis(2-amino-4,6-dimetoxypyrimidine) (3) was synthesized by reduction of 2-amino-4,6-dimethoxy-5-thiocyanatopyrimidine for the first time, and its structure was confirmed by X-ray crystallographic analysis. Novel binuclear antimony(III) compound of (3), {Sb[5,5'-disulfanediylbis(2-amino-4,6-dimetoxypyrimidine)]Cl-3}(2) (4) and mononuclear antimony(III) compounds, SbL2O3, [L: 2-amino-5-thioI-4,6-dimethoxy pyrimidine (2) and 2-amino-5-(1H-tetrazol-5-ylthio)-4,6-dimethoxypyrimidine (6)] were synthesized and characterized with the help of elemental analysis, molecular conductivity, FT-IR,H-1-NMR and LC-MS techniques. The geometrical structures optimized by a DFT/B3LYP/LANL2DZ method of the compounds, indicated that monomeric compounds have square pyramidal shape. Both antileishmanial activity against Leishmania tropica promastigote and glutathione reductase inhibitory activity were determined in vitro. The results showed that (3) has the best biological activity. (C) 2015 Elsevier B.V. All rights reserved. |
| Anahtar Kelimeler |
| Antileishmanial activity | Antimony(III) complexes | Glutathione reductase inhibition |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY |
| Dergi ISSN | 1011-1344 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2015 |
| Cilt No | 153 |
| Sayı | 1 |
| Sayfalar | 206 / 214 |
| Doi Numarası | 10.1016/j.jphotobiol.2015.09.022 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1011134415003176 |
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 8 |
| Google Scholar | 17 |
