Acetohydroxyacid Synthase (AHAS) Inhibitor‐Based Commercial Sulfonylurea Herbicides as Glutathione Reductase Inhibitors: in Vitro and in Silico Studies
Yazarlar (6)
Sedat Sel Istanbul Üniversitesi
Doç. Dr. Turgay TUNÇ Kırşehir Ahi Evran Üniversitesi, Türkiye
Ahmet Buğra Ortaakarsu Gazi Üniversitesi
Serhat Mamaş Gazi Üniversitesi
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Mehmet Sayım Karacan Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ChemistrySelect (Q2) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2022 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 7 / 38 / 1–5 | DOI | 10.1002/slct.202202235 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202202235 | ||
| Özet |
| In this study, in vitro inhibitory effect of AHAS inhibiting‐based commercial sulfonylurea herbicides on human GR and S. cerevisiae GR was determined by electrochemical method. Our findings, the first report in literature, show that the four commercial herbicides were found to be the inhibitors in the range of 4.90–9.75 μM for ScGR, and in the range of 8.54–18.84 μM for hGR. Global reactivity descriptors (energy gaps, electronegativity, hardness and electrophilicity index) of the herbicides were calculated by DFT/B3LYP/6‐31G(d,p) method in gas phase. The electrochemical behavior of the herbicides was studied by cyclic voltammetry. Single‐electron half‐wave reduction potentials and global reactivity descriptors were correlated with the IC50 values of the herbicides. Molecular docking analysis using Schrödinger Suite was applied to examine the interaction between the herbicides and human GR (PDB ID … |
| Anahtar Kelimeler |
| AHAS inhibitors | glutathione reductase | herbicides | molecular docking | sulphonylurea |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 7 |
| Scopus | 7 |