| Yazarlar |
Hakan Tahtacı
Karabük Üniversitesi, Türkiye |
|
Mustafa Er
Karabük Üniversitesi, Türkiye |
Doç. Dr. Tuncay KARAKURT
Ahi Evran Üniversitesi, Türkiye |
|
Kemal Sancak
Karadeniz Teknik Üniversitesi, Türkiye |
| Özet |
| A new synthesis was developed for 1,3,4-thiadiazol-2(3H)-one derivatives, based on a new arrangement on the thiadiazole ring with an intramolecular addition-elimination reaction. To this end, starting from 5-methyl-1,3,4-thiadiazole-2-thiol (1), derivatives of 3-((un)substituted benzyl)-5-methyl-1,3,4-thiadiazol-2(3H)-one (7a-g) and ((un)substituted phenyl)-2-oxoethyl)-5-methyl,3,4-thiadiazol-2(3H)-one (10-15) were synthesized (in yields of 81-88% and 63-71%, respectively). The structures of all synthesized compounds were characterized using IR, H-1 NMR, and C-13 NMR spectroscopy, and elemental analysis, mass spectroscopy and X-ray diffraction analysis (compounds 3c, 7b-f and 10) techniques. This study presents a new and effective reaction path for the synthesis of 1,3,4-thiadiazol-2(3H)-one derivatives. (C) 2017 Elsevier Ltd. All rights reserved. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazole | 1,3,4-Thiadiazol-2(3H)-one | Intramolecular addition-elimination reaction | A novel method |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TETRAHEDRON |
| Dergi ISSN | 0040-4020 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2017 |
| Cilt No | 73 |
| Sayı | 30 |
| Sayfalar | 4418 / 4425 |
| Doi Numarası | 10.1016/j.tet.2017.06.006 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0040402017306257 |
| Atıf Sayıları | |
| WoS | 10 |
