Synthesis of 1,3,4-thiadiazol-2(3 H )-one derivatives via an unexpected intramolecular addition-elimination reaction of 1,3,4-thiadiazoles
Yazarlar (4)
Karabük Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
Doç. Dr. Tuncay KARAKURT
Kırşehir Ahi Evran Üniversitesi, Türkiye
Karadeniz Technical University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Tetrahedron | ||
| Dergi ISSN | 0040-4020 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2017 |
| Cilt / Sayı / Sayfa | 73 / 30 / 4418–4425 | DOI | 10.1016/j.tet.2017.06.006 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0040402017306257 | ||
| Özet |
| A new synthesis was developed for 1,3,4-thiadiazol-2(3H)-one derivatives, based on a new arrangement on the thiadiazole ring with an intramolecular addition-elimination reaction. To this end, starting from 5-methyl-1,3,4-thiadiazole-2-thiol (1), derivatives of 3-((un)substituted benzyl)-5-methyl-1,3,4-thiadiazol-2(3H)-one (7a-g) and ((un)substituted phenyl)-2-oxoethyl)-5-methyl,3,4-thiadiazol-2(3H)-one (10-15) were synthesized (in yields of 81-88% and 63-71%, respectively). The structures of all synthesized compounds were characterized using IR, H-1 NMR, and C-13 NMR spectroscopy, and elemental analysis, mass spectroscopy and X-ray diffraction analysis (compounds 3c, 7b-f and 10) techniques. This study presents a new and effective reaction path for the synthesis of 1,3,4-thiadiazol-2(3H)-one derivatives. (C) 2017 Elsevier Ltd. All rights reserved. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazole | 1,3,4-Thiadiazol-2(3H)-one | Intramolecular addition-elimination reaction | A novel method |
Science Direct
Synthesis of 1,3,4-thiadiazol-2(3 H )-one derivatives via an unexpected intramolecular addition-elimination reaction of 1,3,4-thiadiazoles
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 13 |
| SCOPUS | 17 |
| Google Scholar | 18 |