Synthesis of 1,3,4-thiadiazol-2(3 H )-one derivatives via an unexpected intramolecular addition-elimination reaction of 1,3,4-thiadiazoles
Yazarlar (4)
Hakan Tahtacı Karabük Üniversitesi, Türkiye
Mustafa Er Karabük Üniversitesi, Türkiye
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
Kemal Sancak Karadeniz Technical University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Tetrahedron | ||
| Dergi ISSN | 0040-4020 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2017 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 73 / 30 / 4418–4425 | DOI | 10.1016/j.tet.2017.06.006 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0040402017306257 | ||
| Özet |
| A new synthesis was developed for 1,3,4-thiadiazol-2(3H)-one derivatives, based on a new arrangement on the thiadiazole ring with an intramolecular addition-elimination reaction.To this end, starting from 5-methyl-1,3,4-thiadiazole-2-thiol (1), derivatives of 3-((un)substituted benzyl)-5-methyl-1,3,4-thiadiazol-2(3H)-one (7a-g) and ((un)substituted phenyl)-2-oxoethyl)-5-methyl-1,3,4-thiadiazol-2(3H)-one (10–15) were synthesized (in yields of 81–88% and 63–71%, respectively). The structures of all synthesized compounds were characterized using IR, 1H NMR, and 13C NMR spectroscopy, and elemental analysis, mass spectroscopy and X-ray diffraction analysis (compounds 3c, 7b-f and 10) techniques.This study presents a new and effective reaction path for the synthesis of 1,3,4-thiadiazol-2(3H)-one derivatives. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazol-2(3H)-one | 1,3,4-Thiadiazole | A novel method | Intramolecular addition-elimination reaction |
Science Direct
Synthesis of 1,3,4-thiadiazol-2(3 H )-one derivatives via an unexpected intramolecular addition-elimination reaction of 1,3,4-thiadiazoles
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| Atıf Sayıları | |
| Google Scholar | 19 |
| Scopus | 4 |
| Web of Science | 13 |