title A Novel Class Substituted Imidazo[2,1‐ ib/i ][1,3,4]thiadiazole Derivatives: Synthesis, Characterization, In Vitro Biological Activity, and Potential Inhibitors Design Studies/title
Yazarlar (5)
Mustafa Er Karabük Üniversitesi, Türkiye
Farid Ahmadov
Karabük Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
Şahin Direkel Giresun Üniversitesi, Türkiye
Hakan Tahtaci Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2019 |
| Cilt / Sayı / Sayfa | 4 / 48 / 14281–14290 | DOI | 10.1002/slct.201903886 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201903886 | ||
| Özet |
| In this study, imidazo[2,1‐b][1,3,4]thiadiazole derivatives were designed and synthesized. All of the synthesized compounds were characterized by 1H and 13C nuclear magnetic resonance (1H NMR and 13C NMR), fourier‐transform infrared spectroscopy (FT‐IR), elemental analysis, mass spectrometry, and X‐ray diffraction. The synthesized compounds were tested for antileishmanial activity against two Leishmania species and antibacterial activity against nine bacterial species in the study. It was observed that 2‐(4‐Fluorobenzylthio)‐6‐(4‐fluorophenyl)imidazo[2,1‐b][1,3,4]thiadiazole (5) had the highest antileishmanial activity (MIC: 625 μg/mL). Also, 4‐(2‐(4‐fluorobenzylthio)imidazo[2,1‐b][1,3,4]thiadiazol‐6‐yl)benzonitrile (10), 2‐(4‐fluorobenzylthio)‐6‐(4‐phenylphenyl)imidazo[2,1‐b][1,3,4]thiadiazole (11), and 4‐(2‐(4‐methoxybenzyl)imidazo[2,1‐b][1,3,4]thiadiazol‐6‐yl)benzonitrile (25) were found to be … |
| Anahtar Kelimeler |
| Ab initio calculations | ADME | Biological activity | Imidazo[2,1-b][1,3,4]thiadiazole | Molecular docking |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 16 |
| Scopus | 14 |
| Web of Science | 13 |