Synthesis, characterization, preliminary SAR and molecular docking study of some novel substituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as antifungal agents
Yazarlar (6)
Öğr. Gör. Mustafa Er Karabük Üniversitesi, Türkiye
Buğracan Ergüven
Karabük Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
Hakan Tahtacı Karabük Üniversitesi, Türkiye
Abdurrahman Onaran Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
Abdulilah Ece Biruni Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Medicinal Chemistry Research (Q3) | ||
| Dergi ISSN | 1054-2523 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2017 |
| Cilt / Sayı / Sayfa | 26 / 3 / 615–630 | DOI | 10.1007/s00044-017-1782-4 |
| Makale Linki | http://dx.doi.org/10.1007/s00044-017-1782-4 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| The aim of this study was to synthesize imidazo[2,1-b][1,3,4]thiadiazole derivatives, characterize them with various spectroscopic methods and investigate their antifungal activities. 2-Αmino-1,3,4-thiadiazole derivatives 2a, b were synthesized by reacting nitrile compounds 1a, b with thiosemicarbazide (yields 75 and 88%). We then synthesized imidazo[2,1-b][1,3,4]thiadiazole derivatives 4–21, the target compounds, from the reactions of 2-amino-1,3,4-thiadiazole derivatives 2a, b with phenacyl bromide derivatives 3 (yields 52–69%). The structures of all synthesized compounds were characterized by infrared, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, elemental analysis and mass spectroscopy and X-ray diffraction analysis was also used for the compounds 7, 8, 10, and 17. Subsequently, in vitro antifungal activity tests were applied to all synthesized compounds. Inhibition zones … |
| Anahtar Kelimeler |
| 2-Amino-[1,3,4]thiadiazole | Antifungal activity | Imidazo[2,1-b][1,3,4]thiadiazole | Molecular docking | Phenacyl bromide | SAR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 35 |
| Scopus | 38 |
| Google Scholar | 45 |