| Yazarlar |
Dağlı Meltem
Karabük Üniversitesi, Türkiye |
|
Mustafa Er
Türkiye |
|
Tuncay Karakurt
Kırşehir Ahi Evran Üniversitesi |
|
Abdurrahman Onaran
Akdeniz Üniversitesi, Türkiye |
|
Hakan Alıcı
Türkiye |
|
Hakan Tahtacı
Karabük Üniversitesi, Türkiye |
| Özet |
| In this study, a novel series of 2,6-disubstituted and 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives were synthesized starting from 2-amino-1,3,4-thiadiazole derivatives. Structures of the synthesized compounds were characterized using various analysis techniques. Then, in vitro biological activity tests were carried out for all synthesized compounds and they were found to show moderate to good activity against all bacteria and fungi tested. Next, molecular docking simulations were performed to observe the inhibition effect of the synthesized compounds on the 3R9C receptor and support their biological activity results. Finally, the pharmacokinetic, ADME and toxicity properties of all compounds were examined using FAF-Drugs and ProTox webservers and it was concluded that they had acceptable toxicity and ADME properties. |
| Anahtar Kelimeler |
| Ab initio calculations | ADME | Biological activity | Imidazo[2 | 1-b][1 | 3 | 4]thiadiazole | Mannich bases |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CHEMISTRYSELECT |
| Dergi ISSN | 2365-6549 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2020 |
| Cilt No | 5 |
| Sayı | 38 |
| Sayfalar | 11753 / 11763 |
| Doi Numarası | 10.1002/slct.202002821 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202002821 |
| Atıf Sayıları | |
| WoS | 14 |
