Synthesis, Characterization, Antimicrobial Evaluation, and Computational Investigation of Substituted Imidazo[2,1‐b][1,3,4]Thiadiazole Derivatives
Yazarlar (6)
Karabük Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
Doç. Dr. Tuncay KARAKURT
Kırşehir Ahi Evran Üniversitesi, Türkiye
Akdeniz Üniversitesi, Türkiye
Zonguldak Bulent Ecevit University, Türkiye
Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2020 |
| Cilt / Sayı / Sayfa | 5 / 38 / 11753–11763 | DOI | 10.1002/slct.202002821 |
| Makale Linki | https://doi.org/10.1002/slct.202002821 | ||
| Özet |
| In this study, a novel series of 2,6-disubstituted and 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives were synthesized starting from 2-amino-1,3,4-thiadiazole derivatives. Structures of the synthesized compounds were characterized using various analysis techniques. Then, in vitro biological activity tests were carried out for all synthesized compounds and they were found to show moderate to good activity against all bacteria and fungi tested. Next, molecular docking simulations were performed to observe the inhibition effect of the synthesized compounds on the 3R9C receptor and support their biological activity results. Finally, the pharmacokinetic, ADME and toxicity properties of all compounds were examined using FAF-Drugs and ProTox webservers and it was concluded that they had acceptable toxicity and ADME properties. |
| Anahtar Kelimeler |
| Ab initio calculations | ADME | Biological activity | Imidazo[2 | 1-b][1 | 3 | 4]thiadiazole | Mannich bases |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 24 |
| SCOPUS | 27 |
| Google Scholar | 32 |